| Cat. No. |
Product Name |
Information |
| PC-21274 |
ARUK2007145
PI5P4Kα/γ inhibitor
|
ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ. |
| PC-21268 |
NKG2D inhibitor 4e
NKG2D inhibitor
|
NKG2D inhibitor 4e is a small-molecule protein-protein interaction inhibitor for NKG2D with IC50 of 2.2 uM, disrupts the interaction between NKG2D and multiple protein ligands through allosteric modulation of the NKG2D receptor dimer/ligand interface. |
| PC-21262 |
C105SR
Cyclophilin inhibitor
|
C105SR is small-molecule cyclophilin inhibitor with IC50 of 5 nM for inhibition of CypD PPIase activity and 9 nM for mitochondrial swelling. |
| PC-21260 |
ABR-238901
S100A9 inhibitor
|
ABR-238901 is an orally active and potent S100A9 blocker, inhibits the interaction of S100A9 with its receptors. |
| PC-21254 |
5M-8OH-Q
UGGT inhibitor
|
5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases. |
| PC-21246 |
HAMNO
RPA inhibitor
|
HAMNO (NSC 111847) is a small molecule protein interaction inhibitor of replication protein A (RPA), specifically inhibits RPA DNA binding domain F (DBD-F), inhibits dsDNA unwinding with IC50 of 9 uM. |
| PC-21242 |
Nitisinone
4-HPPD inhibitor
|
Nitisinone (NTBC, Nitisone, SC0735) is a potent, orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with IC50 of 173 nM. |
| PC-21232 |
FMP-201300
IP6K inhibitor
|
FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively. |
| PC-21231 |
Glutamate-cysteine ligase inhibitor EN25
Glutamate-cysteine ligase inhibitor
|
Glutamate-cysteine ligase inhibitor EN25 is a covalent inhibitor of the glutamate-cysteine ligase (GCL) with IC50 of 16 uM, targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL. |
| PC-21228 |
LX-6171
Proline transporter inhibitor
|
LX-6171 is a small molecule proline transporter (SLC6A7) inhibitor with potential for treating cognitive and other disorders. |
| PC-21227 |
LP-403812
Proline transporter inhibitor
|
LP-403812 is a specific small molecule inhibitor of mammalian proline transporter (PROT), inhibits PROT-mediated proline uptake with IC50 of 0.1 uM on both recombinant human and mouse PROT. |
| PC-21217 |
O-1918
GPR18 antagonist
|
O-1918 is a selective, potent antagonist of non-canonical cannabinoid GPR18, does not bind to CB(1) or CB(2) receptors and does not cause vasorelaxation at concentrations up to 30 uM. |
