| Cat. No. |
Product Name |
Information |
| PC-27404 |
Alcedaplin
APOL1 inhibitor
|
Alcedaplin is a small molecule inhibitor of apolipoprotein L1 (APOL1) function. |
| PC-27395 |
BCT2029
BLVRB inhibitor
|
BCT2029 is a potent Biliverdin IXb reductase (BLVRB, biliverdin reductase IXβ) inhibitor, inhibits BLVRB reductive activity using both FMN (flavin mononucleotide, IC50=194 nM) and DCPIP (2,6-dichlorophenolindophenol; IC50=28 nM) as substrates. |
| PC-27394 |
BCT2102
BLVRB ligand
|
BCT2102 is a cell-permeable acceptor ligand of Biliverdin IXb reductase (BLVRB), demonstrates specific energy transfer and inform equilibrium binding affinities, target engagement, and residence time analyses in vitro and cellular nanoBRET assays. |
| PC-27393 |
BCT2101
BLVRB ligand
|
BCT2101 is a cell-permeable acceptor ligand of Biliverdin IXb reductase (BLVRB), demonstrates specific energy transfer and inform equilibrium binding affinities, target engagement, and residence time analyses in vitro and cellular nanoBRET assays. |
| PC-27391 |
[18F]FB-HTL
PET ligand
|
[18F]FB-HTL is a BBB-penetrable fluorine-18-labelled small-molecule HaloTag ligand and PET reporter ligand for quantitative imaging of gene expression in the brain. |
| PC-27390 |
Spermidine
CAS 124-20-9
|
Spermidine is a polyamine essential for various biological processes, has long been recognized as a signaling molecule, promotes cell growth, regeneration, and autophagy, targets GGA-rich small RNAs for virulence regulation. |
| PC-27388 |
ALOX15-IN-1
ALOX15 inhibitor
|
ALOX15-IN-1 (Compound 8b) is a potent, substrate-selective and allosteric inhibitor of mammalian Arachidonic acid 15-lipoxygenase (ALOX15) orthologs, inhibits linoleate oxygenase activity of rabbit and human ALOX15 with IC50 of 0.04 uM, without affecting arachidonic acid oxygenation. |
| PC-27382 |
SKF-91488
HNMT inhibitor
|
SKF-91488 (Homodimaprit, SKF 91488) is a potent, noncompetitive histamine N-methyltransferase (HNMT) inhibitor with Ki of 0.9 uM, blocks histamine metabolism and increases histamine concentrations, can increase blood pressure and enhance bronchoconstriction. |
| PC-27381 |
CC-156
HSD17B1 inhibitor
|
CC-156 is a potent, selective 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1, HSD17B1) with IC50 of 44 nM. |
| PC-27367 |
CN045
OPC differentiation stimulator
|
CN045 is a brain-penetrable enhancer of oligodendrocyte progenitor cells (OPCs) differentiation and remyelination, stimulates differentiation of mouse OPCs into oligodendrocytes with EC50 of 40 nM in the OPC differentiation assay. |
| PC-27358 |
Pyripyropene A
ACAT2 inhibitor
|
Pyripyropene A (Pyri-A, PPPA) is a highly potent and selective inhibitor of acyl CoA:cholesterol acyltransferase 2 (ACAT2, Sterol O-acyltransferase 2, SOAT2) with IC50 of 70 nM, >1000-fold selective over SOAT1/ACAT1. |
| PC-27357 |
DHODH inhibitor HL6
DHODH inhibitor
|
DHODH inhibitor HL6 is a potent, CoQ-competitive DHODH inhibitor with Ki of 2.39 nMand IC50 of 5.29 nM (recombinant human DHODH), disrupts WDR77 stabilization, thereby attenuating PRMT5/WDR77-dependent AKT signaling in PIK3CA-mutant CRC. |
