| Cat. No. |
Product Name |
Information |
| PC-27923 |
3-Hydroxyhippuric acid
Kynureninase inhibitor
|
3-Hydroxyhippuric acid is an inhibitor of kynureninase (KYNU) with Ki of 60 uM, affects the spatial overflow of mtROS from mitochondria to the endoplasmic reticulum (ER). |
| PC-27917 |
Pinoresinol
β-glucuronidase inhibitor
|
Pinoresinol ((+)-Pinoresinol) is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds, shows inhibitory activity against rat intestinal α-glucosidase with IC50 of 34.3 uM, inhibits proliferation and induces differentiation on human HL60 leukemia cells, also exerts enzymatic β-glucuronidase inhibitory activity with IC50 of 27.9 uM. |
| PC-27845 |
Thiazolidine-2-carboxylate
PRODH inhibitor
|
Thiazolidine-2-carboxylate (T2C) is a covalent, irreversible inhibitor of proline dehydrogenase (PRODH), covalently binds to the N5 of the FAD in the PRODH domain. also inhibits pyrroline-5-carboxylate reductase 1 (PYCR1). |
| PC-27844 |
N-Propargylglycine
PRODH inhibitor
|
N-propargylglycine (N-PPG) is a covalent, irreversible suicide inhibitor of proline dehydrogenase (PRODH), activates mitochondrial PRODH decay, shows anticancer activity and brain-enhancing mitohormesis properties |
| PC-27832 |
Eflornithine hydrochloride hydrate
Ornithine decarboxylase inhibitor
|
Eflornithine hydrochloride hydrate (DFMO, MDL71782, RMI71782, α-difluoromethylornithine) is an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits polyamine biosynthesis. |
| PC-27826 |
DDAH1 inhibitor A8
DDAH1 inhibitor
|
DDAH1 inhibitor A8 is a small molecule inhibitor of dimethylarginine dimethylaminohydrolase 1 (DDAH1) with IC50 of 176 uM, significantly suppresses vasculogenic mimicry in TNBC cells. |
| PC-27780 |
A8535
GPR27 agonist
|
A8535 is a selective small-molecule GPR27 (SREB1) agonist. |
| PC-27778 |
Phoenixin-20
Neuropeptide
|
Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, stimulates hypothalamo-pituitary-gonadal hormones and regulates reproductive processes in mammals, promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. |
| PC-27764 |
IMYX-3
RAB27 inhibitor
|
IMYX-3 is a first-in-class small molecule oral inhibitor of RAB27, inhibits PMA-activated human neutrophil ROS with IC50 of 0.36 uM in human neutrophils, reduces neutrophil-mediated damage by decreasing ROS, degranulation, and NET formation. |
| PC-27758 |
PI5P4Kγ-IN-1
PI5P4Kγ inhibitor
|
PI5P4Kγ-IN-1 is a potent, selective and ATP-competitive chemical probe inhibitor for PI5P4Kγ with Kd of 19 nM and IC50 of 67 nM, effectively inhibits PI5P4Kγ function and activates the mTORC1 signaling pathway in cells. |
| PC-27718 |
UM-1098
Mincle agonist, Vaccine adjuvant
|
UM-1098 is a synthetic macrophage-Inducible C-type Lectin (Mincle) agonist, induces Th17, Th1, Th2 polarizing innate cytokines in mouse PBMCs, induces strong Th1 and Th17 immunity after vaccination with Mtb antigens. |
| PC-27691 |
GO1323
HsCRY1 modulator
|
GO1323 is a photopharmacological light-switchable modulator of human clock protein cryptochrome-1 (HsCRY1), selectively binds to HsCRY1, enables light-controlled manipulation of the circadian rhythm via photoisomerization. |
