| Cat. No. |
Product Name |
Information |
| PC-27131 |
UR214-9
Septin inhibitor
|
UR214-9 is a forchlorfenuron (FCF) analog and inhibitor of septin oligomeric assembly via preventing incorporation of SEPT2/7/9, into canonical hetero-octamers, decreases viability and proliferation in both ovarian and endometrial cancer cell lines, selectively suppress HER2 expression. |
| PC-27130 |
VU0619195
Ordered membrane domains inhibitor
|
VU0619195 is a small molecule disruptor of ordered membrane domains in cells, destabilize raft formation and decrease protein partitioning reduced the raft affinities of both PMP22 and MAL with EC50 of 1.62 uM and 1.37 uM. |
| PC-27125 |
CTL4 inhibitor DT-13
CTL4 inhibitor
|
CTL4 inhibitor DT-13 is a potent small molecule choline transporter-like protein 4 (CTL4) inhibitor with IC50 of 12.47 uM, directly binds to CTL4 with MST Kd of 0.64 uM, inhibits CTL4-mediated choline uptake. |
| PC-27098 |
Creatine transporter 1-IN-1
CT1/SLC6A8 inhibitor
|
Creatine transporter 1-IN-1 is a small molecule creatine transporter 1 (CT1, SLC6A8), inhibits substrate uptake by CT1 in CT1 expressing HEK293 cells with IC50 of 55 uM. |
| PC-27082 |
OICR-403184
PKR inhibitor
|
OICR-403184 is a potent, selective inhibitor of RNA-dependent protein kinase PKR with IC50 of 263 nM, shows minimal activity against related eIF2α kinases and BRAF. |
| PC-27060 |
CIB-Q22
Pyruvate carboxylase inhibitor
|
CIB-Q22 is a potent pyruvate carboxylase (PC) inhibitor with IC50 of 1.74 nM, suppresses HCC cell viability (IC50=25.18 nM). |
| PC-27059 |
Pyruvate Carboxylase-IN-1
Pyruvate carboxylase inhibitor
|
Pyruvate Carboxylase-IN-1 (Compound 37) is a potent pyruvate carboxylase (PC) inhibitor with IC50 of 204 nM and 104 nM for PC in cell lysates and cells, shows antiproliferative activity against human hepatocellular carcinoma (HCC). |
| PC-27058 |
Pyruvate Carboxylase-IN-5
Pyruvate carboxylase inhibitor
|
Pyruvate Carboxylase-IN-5 (Compound 6m) is a selective pyruvate carboxylase (PC) inhibitor with IC50 of 3.4 uM. |
| PC-27057 |
U73343
CH25H inhibitor
|
U-73343 (U73343) an inactive analog of phospholipase C (PLC) inhibitor U73122, also is a potent enhancer of oligodendrocyte formation that induces 8,9-unsaturated sterol accumulation by inhibition of cholesterol biosynthesis enzyme sterol 14-reductase, also inhibits cholesterol 25-hydroxylase (CH25H). |
| PC-27050 |
Commendamide
GPR132 agonist
|
Commendamide is natively produced by commensal Bacteroides and specific agonist of GPCR G2A/GPR132 with EC50 of 11.8 uM, attenuates skeletal muscle ferroptosis in vitro. |
| PC-27048 |
SB-583831
GPR132 agonist
|
SB-583831 is a potent, selective agonist of G‐protein‐coupled receptor GPR132 (G2A) with pEC50 of 7.7 and 7.3 in yeast and β‐arrestin assays (human GPR132a). |
| PC-26995 |
SIPI11594
MPC inhibitor
|
SIPI11594 is a small molecule mitochondrial pyruvate carrier (MPC) inhibitor, shows cellular lactate production-enhancing activity, significantly accelerates hair regrowth and anagen entry. |
