| Cat. No. |
Product Name |
Information |
| PC-21360 |
Heparanase-1 inhibitor 18
Heparanase-1 inhibitor
|
Heparanase-1 inhibitor 18 is a potent, selective inhibitor of heparanase-1 (HPSE1) with IC50 of 442 nM. |
| PC-21358 |
PAT1inh-A0030
SLC26A6 (PAT1) inhibitor
|
PAT1inh-A0030 is a potent and selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor with IC50 of 1.0 uM, shows no activity on relevant ion transporters/channels (SLC26A3, SLC26A4, SLC26A9, CFTR, TMEM16A). |
| PC-21339 |
Butaselen
Thioredoxin reductase inhibitor
|
Butaselen is a small molecule inhibitor of thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor activity, inhibits the growth of various human cancer cell lines. |
| PC-21334 |
Aster inhibitor AI-3d
Asters inhibitor
|
Aster inhibitor AI-3d is a potent, selective small molecule inhibitor of Aster proteins (encoded by the Gramd1a-c genes) with IC50 of 0.11 μM, 0.06 μM and 0.71 uM for Aster-A, Aster-B, and Aster-C, respectively. |
| PC-21327 |
ENPP1 inhibitor 29f hydrochloride
ENPP1 inhibitor
|
ENPP1 inhibitor 29f hydrochloride is a potent, orally active inhibitor of ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), inhibits the cGAMP hydrolysis by ENPP1 in vitro with IC50 of 68 nM. |
| PC-21326 |
ENPP1 inhibitor 29f
ENPP1 inhibitor
|
ENPP1 inhibitor 29f is a potent, orally active inhibitor of ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), inhibits the cGAMP hydrolysis by ENPP1 in vitro with IC50 of 68 nM. |
| PC-21318 |
PSB-22034
MRGPRX4 agonist
|
PSB-22034 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 11.2 nM/32.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively. |
| PC-21295 |
PTC-124
Readthrough promoter
|
PTC-124 (Ataluren, PTC124) is an orally bioavailable small molecule that selectively induces ribosomal readthrough of premature but not normal termination codons. |
| PC-21293 |
KRP-6
MIF inhibitor
|
KRP-6 is a potent and highly selective macrophage migration inhibitory factor (MIF) ketonase inhibitor with IC50 of 4.31 uM, significantly reduces MIF-induced neutrophil migration. |
| PC-21275 |
ARUK2002821
PI5P4Kα inhibitor
|
ARUK2002821 is a potent, selective PI5P4Kα inhibitor with pIC50 of 8.0, >1000-fold selective over PI5P4Kγ. |
| PC-21274 |
ARUK2007145
PI5P4Kα/γ inhibitor
|
ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ. |
| PC-21268 |
NKG2D inhibitor 4e
NKG2D inhibitor
|
NKG2D inhibitor 4e is a small-molecule protein-protein interaction inhibitor for NKG2D with IC50 of 2.2 uM, disrupts the interaction between NKG2D and multiple protein ligands through allosteric modulation of the NKG2D receptor dimer/ligand interface. |
