| Cat. No. |
Product Name |
Information |
| PC-26130 |
SR-1815
SynGAP rescuer
|
SR-1815 is a small molecule multi-kinase inhibitor, rescues SynGAP protein levels in heterozygous KO neurons and in the disease model with Syngap1 haploinsufficiency |
| PC-26113 |
JZ128
PKN3 inhibitor
|
JZ128 is a selective, covalent inhibitor of Protein Kinase N3 (PKN3) with IC50 of 120 nM, targets Cys840 in PKN3, has no activity against CDK7 or CDK12/13. |
| PC-26095 |
Profilin1 inhibitor UP-6
Profilin1 inhibitor
|
Profilin1 inhibitor UP-6 is a specific small molecule inhibitor of Actin-binding protein profilin1 (Pfn1), inhibits Pfn1-actin interaction and tumor angiogenesis. |
| PC-26091 |
Etoxazole
Acaricide
|
Etoxazole (YI-5301) is a highly effective acaricide that affects the nymphs, eggs, and larvae of spider mites by inhibiting chitin biosynthesis. |
| PC-26086 |
IDB-003
Translation inhibitor
|
IDB-003 is an orally active, unique context-dependent inhibitor of human translation that bind to the ribosome peptidyl transferase center (PTC) and inhibits elongation. |
| PC-26085 |
IDB-001
Translation inhibitor
|
IDB-001 is a small molecule, unique context-dependent inhibitor of human translation that bind to the ribosome peptidyl transferase center (PTC) and inhibits elongation. |
| PC-26079 |
TREM2 agonist S9
TREM2 agonist
|
TREM2 agonist S9 is a potent, small molecule Triggering receptor expressed on myeloid cells-2 (TREM2) agonist with MST binding KD of 0.95 uM. |
| PC-26078 |
HCY-NBD
GSTM2 stablizer
|
HCY-NBD is a small molecule stabilizer of Glutathione S-transferase Mu 2 (GSTM2), promotes sulfenylation at Cys174 of GSTM2 and inhibits its K48-linked ubiquitination at this residue, stabilizes GSTM2 protein levels. |
| PC-26076 |
ERX-208
LIPA inhibitor, ERS inducer
|
ERX-208 is a small molecule ERX-41 analog that binds stereospecifically to lysosomal acid lipase A (LIPA), induces endoplasmic reticulum stress (ERS) and apoptosis in a panel of OCa cell lines in vitro (IC50=100 nM). |
| PC-26063 |
Berberrubine chloride
TDP-43 aggregation inhibitor
|
Berberrubine chloride is an orally active metabolite of berberine, alleviates mucosal lesions and inflammation in mouse colitis models, inhibits TDP-43 aggregation and shows anti-inflammatory, anti-tumor, and antiviral activities. |
| PC-26054 |
AGS8-IN-1
AGS8 inhibitor
|
AGS8-IN-1 is a small molecule inhibitor of activator of G-protein signaling 8 (AGS8), effectively inhibits the formation of the AGS8-Gβγ complex, attenuates VEGF-induced phosphorylation of signaling molecules and inhibits tube formation and migration of HUVECs. |
| PC-26035 |
SecA activator HSI#6
SecA activator
|
SecA activator HSI#6 is a small molecule, specific and allosteric activator of SecA dependent secretion, binds onto SecA and allosterically activates the translocase with AC50 of 3.76 uM, activates the soluble, membrane-bound and at-translocation-site SecA states. |
