Chemical Structure : CD80 inhibitor 6
CAS No.:
848607-77-2
CD80 inhibitor 6
(CD80-IN-6)
Catalog No.: PC-22887Not For Human Use, Lab Use Only.
CD80 inhibitor 6 is a specific small molecule inhibitor of human CD80 with SPR KD of 2.7 nM, antagonize CD28 (TR_FRET EC50=2.4 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CD80 inhibitor 6 is a specific small molecule inhibitor of human CD80 with SPR KD of 2.7 nM, antagonize CD28 (TR_FRET EC50=2.4 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays.
CD80 inhibitor 6 binds specifically to human CD80 but not the related protein, human CD86, nor human CD28-Fc, nor do the compounds bind mouse, rat, or canine CD80.
CD80 inhibitor 6 inhibits IL-2 secretion in the CD4+ T cell assay with IC50 of 0.75 uM in purified peripheral blood CD4+ primary T cells.
CD80 inhibitor 6 also inhibits TNFα and IFNγ secretion with IC50 values of 0.97 μM and 0.15 μM, respectively.
Physicochemical Properties
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M.Wt
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480.52
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Formula
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C25H26F2N6O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-(cyclohexylamino)propyl)-4-(6,9-difluoro-3-oxo-3,5-dihydro-2H-pyrazolo[4,3-c]cinnolin-2-yl)benzamide
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References
1. Philip Huxley, et al. Chem Biol. 2004 Dec;11(12):1651-8.
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