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Chemical Structure : BI-9787
Catalog No.: PC-22964Not For Human Use, Lab Use Only.
BI-9787 is a potent, selective zwitterionic ketohexokinase (KHK) inhibitor with enzymatic IC50 of 12/12.8 nM (hKHK-A/C), and cellular IC50 of 123 nM in F1P HepG2 assay.
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BI-9787 is a potent, selective zwitterionic ketohexokinase (KHK) inhibitor with enzymatic IC50 of 12/12.8 nM (hKHK-A/C), and cellular IC50 of 123 nM in F1P HepG2 assay.
BI-9787 potently inhibits mKHK-C and rKHK-C with IC50 of 20 and 3.0 nM respectively.
BI-9787 shows >100-fold selectivity for 44 unrelated targets except PDE4D2.
BI-9787 is a high-quality in vitro and in vivo tool compound for investigating the role of fructose metabolism in disease.
| M.Wt | 489.59 | |
| Formula | C24H29F2N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Heine N, et al. Bioorg Med Chem Lett. 2024 Aug 22;112:129930.
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