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BI-9787

Chemical Structure : BI-9787

CAS No.:

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BI-9787 (BI 9787)

Catalog No.: PC-22964Not For Human Use, Lab Use Only.

BI-9787 is a potent, selective zwitterionic ketohexokinase (KHK) inhibitor with enzymatic IC50 of 12/12.8 nM (hKHK-A/C), and cellular IC50 of 123 nM in F1P HepG2 assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BI-9787 is a potent, selective zwitterionic ketohexokinase (KHK) inhibitor with enzymatic IC50 of 12/12.8 nM (hKHK-A/C), and cellular IC50 of 123 nM in F1P HepG2 assay.
BI-9787 potently inhibits mKHK-C and rKHK-C with IC50 of 20 and 3.0 nM respectively.
BI-9787 shows >100-fold selectivity for 44 unrelated targets except PDE4D2.
BI-9787 is a high-quality in vitro and in vivo tool compound for investigating the role of fructose metabolism in disease.

Physicochemical Properties

M.Wt 489.59
Formula C24H29F2N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-(3-((3-cyano-4-(difluoromethyl)-6-((S)-3-(dimethylamino)pyrrolidin-1-yl)pyridin-2-yl)amino)-4-(methylthio)phenyl)-2-methylpropanoic acid

References

1. Heine N, et al. Bioorg Med Chem Lett. 2024 Aug 22;112:129930.

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