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ABCA1 inducer 39

Chemical Structure : ABCA1 inducer 39

CAS No.: 2839627-76-6

ABCA1 inducer 39

Catalog No.: PC-22962Not For Human Use, Lab Use Only.

ABCA1 inducer 39 is a nonlipogenic ABCA1-inducer (NLAI) with EC50 of 0.1 uM, increases ABCA1 expression, enhances APOE lipidation, and reverses multiple AD phenotypes, without increasing triglycerides (TG).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ABCA1 inducer 39 is a nonlipogenic ABCA1-inducer (NLAI) with EC50 of 0.1 uM, increases ABCA1 expression, enhances APOE lipidation, and reverses multiple AD phenotypes, without increasing triglycerides (TG).

Physicochemical Properties

M.Wt 587.48
Formula C24H24Cl2N2O7S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

ethyl 3-chloro-5-(5-chloro-3-(N-(4-ethoxy-3-methoxyphenyl)-N-methylsulfamoyl)thiophene-2-carboxamido)benzoate

References

1. Ganga Reddy Velma, Journal of Medicinal Chemistry August 27, 2024

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