KHK inhibitor 14

Chemical Structure : KHK inhibitor 14

Catalog No.: PC-22965Not For Human Use, Lab Use Only.

KHK inhibitor 14 is a potent ketohexokinase (KHK) inhibitor with IC50 of 59 nM for KHK-A enzymatic assay and IC50 of 196 nM for hepG2 assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KHK inhibitor 14 is a potent ketohexokinase (KHK) inhibitor with IC50 of 59 nM for KHK-A enzymatic assay and IC50 of 196 nM for hepG2 assay.

M.Wt	366.41
Formula	C18H24F2N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((S)-1-(7,7-Difluoro-2-((S)-2-methylazetidin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)pyrrolidin-3-yl)propanoic Acid

1. Guodong Zhu, et al. J Med Chem. 2023 Oct 12;66(19):13501-13515.