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KHK inhibitor 14

Chemical Structure : KHK inhibitor 14

CAS No.: 3034829-40-5

KHK inhibitor 14

Catalog No.: PC-22965Not For Human Use, Lab Use Only.

KHK inhibitor 14 is a potent ketohexokinase (KHK) inhibitor with IC50 of 59 nM for KHK-A enzymatic assay and IC50 of 196 nM for hepG2 assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KHK inhibitor 14 is a potent ketohexokinase (KHK) inhibitor with IC50 of 59 nM for KHK-A enzymatic assay and IC50 of 196 nM for hepG2 assay.

Physicochemical Properties

M.Wt 366.41
Formula C18H24F2N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((S)-1-(7,7-Difluoro-2-((S)-2-methylazetidin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)pyrrolidin-3-yl)propanoic Acid

References

1. Guodong Zhu, et al. J Med Chem. 2023 Oct 12;66(19):13501-13515.

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