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Chemical Structure : DPTIP
CAS No.: 351353-48-5
Catalog No.: PC-22881Not For Human Use, Lab Use Only.
DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor with IC50 of 30 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $438 | In stock | |
| 100 mg | Get quote |
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DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor with IC50 of 30 nM.
DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, decreases exosome release by 50% in astrocytes. DPTIP (10 mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release in vivo.
| M.Wt | 378.45 | |
| Formula | C21H18N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2,6-Dimethoxy-4-(4-phenyl-5-(thiophen-2-yl)-1H-imidazol-2-yl)phenol |
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1. Camilo Rojas, et al. Sci Rep. 2018 Dec 7;8(1):17715.
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