DPTIP

Chemical Structure : DPTIP

CAS No.: 351353-48-5

Catalog No.: PC-22881Not For Human Use, Lab Use Only.

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor with IC50 of 30 nM.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$158	In stock
25 mg	$268	In stock
50 mg	$438	In stock
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Biological Activity

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor with IC50 of 30 nM.
DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, decreases exosome release by 50% in astrocytes. DPTIP (10 mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release in vivo.

Physicochemical Properties

M.Wt	378.45
Formula	C21H18N2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-Dimethoxy-4-(4-phenyl-5-(thiophen-2-yl)-1H-imidazol-2-yl)phenol

References

1. Camilo Rojas, et al. Sci Rep. 2018 Dec 7;8(1):17715.

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DPTIP

Biological Activity

Physicochemical Properties

References

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