| Cat. No. |
Product Name |
Information |
| PC-25339 |
CQ3196
RIOK2 inhibitor
|
CQ3196 is a potent and orally bioavailable RIO kinase 2 (RIOK2) inhibitor with binding Kd of 14 nM, suppresses RIOK2 ATPase activity in vitro with IC50 of 72 nM in an ADP-Glo kinase assays. |
| PC-25307 |
SyntOFF
Syntenin inhibitor
|
SyntOFF is a specific small molecule inhibitor of syntenin with IC50 of 37 uM in HTRF assays, targets the PDZ2 domain of syntenin. |
| PC-25281 |
KI-DX-014
DDX21 inhibitor
|
KI-DX-014 is a specific small-molecule compound capable of inhibiting the interaction of DDX21 with RNA with IC50 of 3.31 uM, directly binds to DDX21-C-terminal domain (HC+CTD) with Kd of 15.9 uM, allosterically attenuates DDX21 ATPase activity. |
| PC-25280 |
PTC-775
MAPT splicing modulator
|
PTC-775 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 4.9 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25279 |
PTC-553
MAPT splicing modulator
|
PTC-553 is a potent splicing modulator compound (SMC) with EC2x value of 12.7 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25278 |
PTC-700
MAPT splicing modulator
|
PTC-700 is a potent splicing modulator compound (SMC) with EC2x value of 20.9 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25277 |
PTC-003
MAPT splicing modulator
|
PTC-003 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 5.2 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25275 |
Cycloleucine
MAT2A inhibitor
|
Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation, is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro, also inhibits MAT2A, Cycloleucine is an antagonist of NMDA receptor associated glycine receptor. |
| PC-25274 |
AGI-24512
MAT2A inhibitor
|
AGI-24512 is a highly potent, cell-active methionine adenosyltransferase 2α (MAT2A) inhibitor with enzymatic IC50 of 8 nM. |
| PC-25267 |
Ac5GlutolNAc
RENBP inhibitor
|
Ac5GlutolNAc is a specific small molecule inhibitor of GlcNAc 2-epimerase (RENBP), selectively enhances the labeling efficiency of tetraacetyl-N-azidoacetylmannosamine (AAM) in antigen-presenting cells (APCs), but not non-APCs. |
| PC-25223 |
AGPAT4 inhibitor CL26
AGPAT4 inhibitor
|
AGPAT4 inhibitor CL26 is a potent, isoform-specific, covalent inhibitor of acylglycerol-3-phosphate o-acyltransferase 4 (AGPAT4) inhibitor with IC50 of 795 nM, binds to Cys228 of AGPAT4. |
| PC-25222 |
ASS1 inhibitor C-01
ASS1 inhibitor
|
ASS1 inhibitor C-01 is a small molecule inhibitor of argininosuccinate synthetase 1 (ASS1), binds to ASS1 directly with SPR Kd of 18.8 nM. |
