| Cat. No. |
Product Name |
Information |
| PC-22607 |
Orpinolide
OSBP inhibitor
|
Orpinolide is a synthetic withanolide analog with potent antileukemic properties, directly targets oxysterol-binding protein OSBP, disrupts Golgi homeostasis via a mechanism that requires active phosphatidylinositol 4-phosphate (PtdIns4P, PI4P) signaling at ER-Golgi membrane interface. |
| PC-22606 |
SABRAC
Acid ceramidase inhibitor
|
SABRAC is a highly potent, irreversible inhibitor of acid ceramidase (AC, aCDase) with Ki of 29.7 nM, induces apoptosis and provides a benefit in mice survival in IDH1 mut oligodendroglioma. |
| PC-22604 |
Oxybipin-2
OSBP inhibitor
|
Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking. |
| PC-22564 |
T-10418
GPR132 agonist
|
T-10418 is a potent, selective agonist of G protein-coupled receptor G2A (GPR132) with EC50 of 0.82 uM. |
| PC-22541 |
PSB-KK1445
GPR18 agonist
|
PSB-KK1445 is a potent and selective GPR18 agonist with EC50 of 45.4 nM and 124 nM for human and mouse GPR18, respectively, shows high selectivity versus related GPCRs CB1 and CB2, cannabinoid-like receptor, GPR55. |
| PC-22534 |
TSLP inhibitor BP79
TSLP inhibitor
|
TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations. |
| PC-22494 |
CCG-1423
MKL1/SRF inhibitor
|
CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer. |
| PC-22481 |
Forchlorfenuron
Septin inhibitor, HER2 inhibitor
|
Forchlorfenuron (CPPU, 4PU30) is a substituted phenylurea compound and synthetic plant cytokinin for inducing somatic embryogenesis in peanut (Arachis hypogaea L.), inhibits septin and protrusion formation, inhibits proliferation, migration, and invasion in human cancer cell lines, affects HIF-1α and HER2. |
| PC-22469 |
BI-43
Glutaminyl cyclase inhibitor
|
BI-43 is a potent, selective glutaminyl cyclase inhibitor with IC50 of 12 nM and 40 nM for both sQC and gQC, respectively. |
| PC-22448 |
CMFT
MIF inhibitor
|
CMFT is a a small molecule inhibitor of the functional interaction between the transcription factor ICBP90 (a.k.a. UHRF1) and the MIF-794 CATT5-8 promoter microsatellite, inhibits MIF mRNA expression in a -794 CATT5-8 length-dependent manner with an IC50 of 470 nM. |
| PC-22442 |
UCM-13369
NPM1 inhibitor
|
UCM-13369 is a small molecule inhibitor of nucleophosmin 1 (NPM1), inhibits NPM1 expression, downregulates the pathway associated with mutant NPM1 C+, inhibits tumorsphere growth of CSCs. |
| PC-22397 |
UNC9750
IPMK inhibitor
|
UNC9750 is a potent selective inhibitor of inositol phosphate multikinase (IPMK) with IC50 of 31.6 nM, inhibits human glioblastoma cell growth and selectively decreases cellular InsP5 abundance. |
