| Cat. No. |
Product Name |
Information |
| PC-49281 |
IL17A inhibitor 10
IL17A inhibitor
|
IL17A inhibitor 10 is a potent and selective, cell-active inhibitor of IL17A C-terminal region with high binding affinity (SPR KD=43 nM), shows inhibition of IL17A/IL7RA-Fc interactions with IC50 of 740 nM. |
| PC-49279 |
RUNX1/ETO inhibitor 7.44
RUNX1-ETO inhibitor
|
RUNX1-ETO inhibitor 7.44 is a first-in-class, small-molecule inhibitor of RUNX1/ETO tetramerization, specifically interferes the nervy homology region 2 (NHR2) domain of ETO mediating tetramerization with Klig value of 3.75 uM. |
| PC-49276 |
CRCD2
NT5C2 inhibitor
|
CRCD2 is a first-in-class specific small molecule inhibitor of the cytosolic 5' nucleotidase II (NT5C2), directly binds to NT5C2 R367Q recombinant protein with KD of 70.9 uM, shows broadly activies against leukemias bearing highly prevalent relapse-associated mutant forms of NT5C2 in vitro and in vivo. |
| PC-49271 |
MY-9B
SARM1 inhibitor
|
MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1. |
| PC-49270 |
WX-02-37
SARM1 inhibitor
|
WX-02-37 is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.5 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1. |
| PC-49267 |
MLL1 CXXC inhibitor 1
MLL1 CXXC inhibitor
|
MLL1 CXXC inhibitor 1 is a small-molecule inhibitor of the MLL1 CXXC domain with IC50 of 7.1 uM, inhibits MLL CXXC domain-DNA binding activity. |
| PC-49247 |
DDX3X helicase 86
DDX3X inhibitor
|
DDX3X helicase 87 is a potent, selective and aller inhibitor of DDX3X helicase activity with IC50 of 7 nM, shows antiviral activity against DENV-2 and WNV with EC50 of 6.3 and 0.88 uM, respectively. |
| PC-49246 |
DDX3X helicase 79
DDX3X inhibitor
|
DDX3X helicase 79 is a potent, selective inhibitor of DDX3X helicase activity with IC50 of 5 nM, shows antiviral activity against DENV-2 and WNV with EC50 of 1.6 and 2.3 uM, respectively. |
| PC-49245 |
DDX3X helicase inhibitor 64
DDX3X inhibitor
|
DDX3X helicase inhibitor 64 is a potent, selective inhibitor of DDX3X helicase activity with IC50 of 0.14 μM, shows promising anti-HCV activity, with an EC50 of 0.2 μM and cytotoxicity of 86 μM. |
| PC-49243 |
FHP01
DDX3X inhibitor
|
FHP01 (BA103) is a potent, small molecule inhibitor of DDX3X helicase activity with IC50 of 0.3 uM in in vitro enzyme assays, exhibits very effective antiproliferative and killing activity against different breast cancer cell types (IC50=3.058 and 3.21 μM in MDA MB 468 and MDA MB 231, respectively). |
| PC-49242 |
TPC2-A1-P
TPC2 agonist
|
TPC2-A1-P is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 10.5 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium. |
| PC-49241 |
TPC2-A1-N
TPC2 agonist
|
TPC2-A1-N is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 7.8 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium. |
