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ClpP agonist TR-27

Chemical Structure : ClpP agonist TR-27

CAS No.: 2185824-92-2

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ClpP agonist TR-27 (TR27)

Catalog No.: PC-49801Not For Human Use, Lab Use Only.

ClpP agonist TR-27 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ClpP agonist TR-27 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.7 nM.
    TR-27 exhibits the growth inhibition with a ClpP-dependent manner in both MDA-MB-231 and HEK293 T-REx cells with IC50 of 90.7 and 46.1 nM, respectively.
    TR-27 exhibits 20-fold improvement in growth inhibition over the parent molecule ONC201.
    TR-27 induces ClpP-dependent proteolysis on the N-terminome of the proteome in MDA-MB-231 cells.

    Physicochemical Properties

    M.Wt 430.94
    Formula C25H23ClN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-chlorobenzyl)-7-(3-ethynylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one

    References

    1. Mark F Mabanglo, et al. Structure. 2023 Feb 2;31(2):185-200.e10.

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