| Cat. No. |
Product Name |
Information |
| PC-27346 |
VAP-1185
Mast cell activator
|
VAP-1185 is a potent small molecule mast cell activator (MCA), induces mouse BMMCs degranulation, promotes a Th1-biased immune response when combined with TLR9 agonist CpG. |
| PC-27345 |
ST101036
Mast cell activator
|
ST101036 is a small molecule mast cell activator (MCA), induces mouse BMMCs degranulation about 91% at 100 uM, and 38% in human LAD2 cells, promotes de novo synthesis of cytokines and induce the release of eicosanoids from mouse MCs. |
| PC-27344 |
OGG1 agonist F01
OGG1 agonist
|
OGG1 agonist F01 is a potent small-molecule agonist with EC50 of 9.1 uM with 8-oxoGua-containing DNA substrate. |
| PC-27343 |
OGG1 agonist F51
OGG1 agonist
|
OGG1 agonist F51 is a potent small-molecule agonist, protects against PQ-induced cytotoxicity in Kasumi-1 cells, binds to catalytic-site rather than allosteric binding. |
| PC-27321 |
C67-47
PGK1 inhibitor
|
C67-47 is a potent and orally efficacious Phosphoglycerate kinase 1 (PGK1) inhibitor, binds strongly to PGK1 with a dissociation constant (Kd) of 63 nM, exhibits potent antiproliferative effects in pancreatic cancer cells. |
| PC-27319 |
G2A antagonist 65
GPR132 antagonist
|
G2A antagonist 65 is a potent, selective G protein coupled receptor 132 (GPR132 or G2A) antagonist with IC50 of 0.69 uM, prevents the 9-HODE-mediated sensitization of capsaicin-induced TRPV1 responses in primary sensory neurons. |
| PC-27318 |
G2A antagonist 31
GPR132 antagonist
|
G2A antagonist 31 is a potent, selective G protein coupled receptor 132 (GPR132 or G2A) antagonist with IC50 of 0.33 uM. |
| PC-27317 |
Lysophosphatidylcholines
9008-30-4
|
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL), induces cell injury, the production of IL-1β and apoptosis, shows proactive effect on sepsis. |
| PC-27301 |
PHB1 inhibitor TD6
Prohibitin 1 inhibitor
|
PHB1 inhibitor TD6 is a highly potent and selective small-molecule inhibitor of Prohibitin 1 (PHB1), exerts potent anti-tumor activities against CRC, effectively suppresses tumor growth and dissemination by disrupting mitochondrial energy metabolism. |
| PC-27300 |
Fluorizoline
Prohibitin binder
|
Fluorizoline is a synthetic molecule that induces apoptosis by selectively targeting prohibitins, directly binds to prohibitin 1 and 2 (PHB1 and PHB2). |
| PC-27289 |
RUN-89
NRF1 activator
|
RUN-89 is a potent, specific activator of transcription factor nuclear factor erythroid 2-related factor 1 (encoded by NFE2L1, NRF1) with EC50 of 3.1 uM. |
| PC-27287 |
Vosoritide
C-type natriuretic peptide analog, NPR2 agonist
|
Vosoritide (BMN-111) is a biologic analogue of C-type natriuretic peptide (CNP) and a potent stimulator of endochondral ossification, acts to restore chondrogenesis through its binding to natriuretic peptide receptor B (NPR-B, NPR2), resulting in the inhibition of downstream signalling pathways of the overactive FGFR3 gene. |
