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Chemical Structure : ARN16186
Catalog No.: PC-22336Not For Human Use, Lab Use Only.
ARN16186 is a potent, specific small molecule inhibitor of N-Acylethanolamine-hydrolyzing acid amidase (NAAA) with IC50 of 23 nM.
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ARN16186 is a potent, specific small molecule inhibitor of N-Acylethanolamine-hydrolyzing acid amidase (NAAA) with IC50 of 23 nM.
ARN16186 displays little to no activity against human acid ceramidase (h-AC) and fatty acid amide hydrolase (h-FAAH) at 10 uM.
ARN16186 inhibits NAAA in a noncovalent manner.
ARN16186 increases PEA and OEA levels and reduces NF-kB and STAT3 DNA-binding activity in the spinal cord of mice.
ARN16186 reduces mononuclear cell infiltrate in the spinal cord and affects the CD4+T lymphocyte population, reduces the progression and severity of symptoms in EAE mice model.
| M.Wt | 417.57 | |
| Formula | C22H31N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sgroi S, et al. Pharmacol Res. 2021 Oct;172:105816.
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