Chemical Structure : ARN16186
CAS No.:
2320555-85-7
ARN16186
(ARN-16186)
Catalog No.: PC-22336Not For Human Use, Lab Use Only.
ARN16186 is a potent, specific small molecule inhibitor of N-Acylethanolamine-hydrolyzing acid amidase (NAAA) with IC50 of 23 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ARN16186 is a potent, specific small molecule inhibitor of N-Acylethanolamine-hydrolyzing acid amidase (NAAA) with IC50 of 23 nM.
ARN16186 displays little to no activity against human acid ceramidase (h-AC) and fatty acid amide hydrolase (h-FAAH) at 10 uM.
ARN16186 inhibits NAAA in a noncovalent manner.
ARN16186 increases PEA and OEA levels and reduces NF-kB and STAT3 DNA-binding activity in the spinal cord of mice.
ARN16186 reduces mononuclear cell infiltrate in the spinal cord and affects the CD4+T lymphocyte population, reduces the progression and severity of symptoms in EAE mice model.
Physicochemical Properties
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M.Wt
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417.57
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Formula
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C22H31N3O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1R,3r,5S)-3-(4-butylphenoxy)-8-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-8-azabicyclo[3.2.1]octane
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References
1. Sgroi S, et al. Pharmacol Res. 2021 Oct;172:105816.
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