| Cat. No. |
Product Name |
Information |
| PC-25595 |
AEPU
sEH inhibitor
|
AEPU is a moderately water soluble, orally-available, highly potent and selective soluble epoxide hydrolase (sEH) inhibitor with IC50 of 14 nM (human sEH), reduces the development of atherosclerosis in apolipoprotein e-knockout mouse model. |
| PC-25592 |
DCLK1 inhibitor 12n
DCLK1 inhibitor
|
DCLK1 inhibitor 12n is a potent, selective Doublecortin-like Kinase 1 (DCLK1) inhibitor with IC50 of 58 nM, exhibits notable DCLK1 inhibitory activity at the cellular level with IC50 of 25 nM. |
| PC-25586 |
RAGE406R
RAGE inhibitor
|
RAGE406R is a small molecule antagonist of RAGE-DIAPH1 interaction, prevents the formation of the RAGE-DIAPH1, binds to cytosolic tail of RAGE (ctRAGE) with Kd of 0.3 nM. |
| PC-25581 |
FOXA1/2 inhibitor compound T
FOXA1/2 inhibitor
|
FOXA1/2 inhibitor compound T is a small molecule inhibitor of collaboration between FOXA1 and FOXA2, disrupt the FOXA1/2 function, binds to forkhead domain of FOXA1 of SPR KD of 100 uM. |
| PC-25580 |
CIA1 free base
COUP-TFII inhibitor
|
CIA1 free base (COUP-TFII inhibitor A1) is a potent and specific inhibitor of COUP-TFII activity, inhibits COUP-TFII–driven NGFIA reporter expression with IC50 of 3.2 uM, disturbs COUP-TFII binding to FOXA1 to regulate target gene expression. |
| PC-25568 |
ELOVL6 inhibitor 1w
ELOVL6 inhibitor
|
ELOVL6 inhibitor 1w (ELOVL6-IN-4) is a potent, selective, and orally available ELOVL6 (long chain fatty acid elongase 6) inhibitor with IC50 of 79 and 94 nM for human and mouse ELOVL6 respectively. |
| PC-25561 |
BI 1595043
Vanin inhibitor
|
BI 1595043 is a potent, selective and orally bioavailable Vanin (vanin‐1 and vanin‐2) inhibitor, demonstrates promising effects on epithelial cell protection and reduction of inflammatory mediators in preclinical studies. |
| PC-25558 |
KCB3602
Lin28-let-7 inhibitor
|
KCB3602 is a specific small-molecule inhibitor of the Lin28–let-7 interaction with IC50 of 4.8 uM in EMSA assays, shows direct binding to Lin28a with SPR KD of 5.9 uM. |
| PC-25556 |
α-difluoromethylornithine
Ornithine decarboxylase inhibitor
|
α-difluoromethylornithine (DFMO, Eflornithine, MDL71782) is a specific, irreversible inhibitor of polyamine biosynthesis enzyme Ornithine decarboxylase (ODC) with biochemicals IC50 of 252 uM, binding competitively with ornithine. |
| PC-25540 |
Ezurpimtrostat hydrochloride
PPT1 inhibitor
|
Ezurpimtrostat hydrochloride (GNS561) is a novel lysosomotropic agent and autophagy inhibitor that induces lysosomal cell death, targets palmitoyl-protein thioesterase 1 (PPT1). |
| PC-25528 |
MDOLL-0286
ARH3 inhibitor
|
MDOLL-0286 is a potent and selective inhibitor for ADP-ribosylhydrolase 3 (ARH3) with IC50 of 2.3 uM, selective against closely related homologues ARH1. |
| PC-25526 |
MSC778
FEN1 inhibitor
|
MSC778 (MSC-778) is a potent, selective, and orally bioavailable inhibitor of Flap endonuclease 1 (FEN1) with IC50 of 3.0 nM and SPR KD of 2.9 nM, >65-fold selective over closely related RAD2 family members EXO1, GEN1 and XPG. |
