| Cat. No. |
Product Name |
Information |
| PC-25235 |
Ofirnoflast
NEK7 inhibitor
|
Ofirnoflast (HT-6184) is first-in-class, allosteric and orally bioavailable NEK7 inhibitor that disrupts NEK7-NLRP3 protein interaction, thereby preventing the formation of the NLRP3 inflammasome. |
| PC-25234 |
(S)-Perillaldehyde
SRD5A1 inhibitor
|
(S)-Perillaldehyde (L-Perillaldehyde) is a major active monomer extracted from Perilla, shows antidepressant-like activity through the olfactory nervous function, also inhibits CRC by targeting SRD5A1, thereby promoting autophagy through the PI3K/AKT pathway. |
| PC-25229 |
Beta-aminopropionitrile
LOX inhibitor
|
Beta-Aminopropionitrile (BAPN, β-Aminopropionitrile) is an irreversible and orally active lysyl oxidase (LOX) inhibitor, targets the active site of LOX or LOXL isoenzymes. |
| PC-25223 |
AGPAT4 inhibitor CL26
AGPAT4 inhibitor
|
AGPAT4 inhibitor CL26 is a potent, isoform-specific, covalent inhibitor of acylglycerol-3-phosphate o-acyltransferase 4 (AGPAT4) inhibitor with IC50 of 795 nM, binds to Cys228 of AGPAT4. |
| PC-25219 |
Chlorogenic acid
CAS 327-97-9
|
Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb, is an orally active with antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension activities. |
| PC-25214 |
I942
EPAC1 agonist
|
I942 is a specific, small molecule partial agonist of cyclic AMP sensor EPAC1 with AC50 of 50 uM, shows no effect on EPAC2. |
| PC-25207 |
YB-B1
YBX1 inhibitor
|
YB-B1 is a small molecule Y-box-binding protein 1 (YBX1) inhibitor, directly binds to YBX1 protein with SPR KD value of 5.67 uM. |
| PC-25203 |
Pin1 inhibitor PiB
Pin1 inhibitor
|
Pin1 inhibitor PiB is a specific small molecule inhibitor of parvulin family peptidyl prolyl isomerase (PPIase) Pin1 with IC50 of 1.5 uM, inhibits Par14 as potently as Pin1 with IC50 of 1.0 uM. |
| PC-25184 |
JX-078
LAT1 inhibitor
|
JX-078 is a potent, selective inhibitor of L-type amino acid transporters LAT1 (SLC7A5), inhibits [3H]-L-leucine uptake into HT-29 cells with IC50 of 121 nM, >10-fold selective over in LAT2. |
| PC-25177 |
Compound 22978-61-6
Tryptase β inhibitor
|
Compound 22978-61-6 (MFCD00173785) is a potent, selective inhibitor of tryptase β, exhibits potent, dose-dependent inhibition of human pancreatic stellate cells (HPSCs) proliferation at 1 uM. |
| PC-25176 |
BMS-354326
Tryptase inhibitor
|
BMS-354326 is a highly potent, selective tryptase inhibitor with IC50 of 1.8 nM, shows excellent selectivity against trypsin and most other related serine proteases. |
| PC-25175 |
BMS-363131
Tryptase inhibitor
|
BMS-363131 is a potent, selective inhibitor of tryptase with IC50 of <1.7 nM, having excellent selectivity versus other serine proteases including trypsin. |
