| Cat. No. |
Product Name |
Information |
| PC-42082 |
TPEN
LIN28 inhibitor
|
TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-25882 |
PPTD free base
ZIP14 inhibitor
|
PPTD free base is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8. |
| PC-25881 |
ZIP14 inhibitor PPTD
ZIP14 inhibitor
|
ZIP14 inhibitor PPTD is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8. |
| PC-25859 |
Lysosome inhibitor LLAD
SLC38A9 inhibitor
|
LLAD is a long-term lysosome-targeting anticancer drug, inhibits SLC38A9 in lysosomes and alkalinizes lysosomes, induces apoptosis through long-term lysosomal damage in vivo and in vitro. |
| PC-25857 |
PF-429242 dihydrochloride
S1P inhibitor
|
PF-429242 dihydrochloride (PF429242) is a potent, selective, reversible and competitive inhibitor of proprotein convertase SREBP site 1 protease (S1P, Subtilisin kexin isozyme-1/SKI-1, MBTPS1) with IC50 of 170 nM. |
| PC-25841 |
3-Nitrooxypropanol
MCR inhibitor
|
3-Nitrooxypropanol (Abrucomstat, 3-NOP) is a small molecule inhibitor of methane formation in the rumen, specifically inhibits methyl-coenzyme M reductase (MCR), inhibit methanogenesis, in vitro and in vivo. |
| PC-25820 |
TP-5801
TNK1 inhibitor
|
TP-5801 is a potent, specific inhibitor of Thirty-eight-negative kinase-1 (TNK1) with IC50 of 1.4 nM, inhibits TNK1-transformed cells. |
| PC-25819 |
AP232
U2AF1-UHM inhibitor
|
AP232 is a specific small molecule splicing factor U2AF-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM). |
| PC-25818 |
DS89092425
PUF60-UHM inhibitor
|
DS89092425 is a small molecule RNA splicing factor PUF60-UHM inhibitor with ITC KD of 83 uM. |
| PC-25817 |
Claudin 5 binder CL5B
CLDN5 binder
|
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery. |
| PC-25807 |
Ciliogenesis inhibitor Nao-3
Ciliogenesis inhibitor
|
Ciliogenesis inhibitor Nao-3 (Naonedin-3) is specific small-molecule inhibitor of ciliogenesis, represses primary ciliogenesis and induces the death of chemoresistant ciliated stem-like cells. |
