| Cat. No. |
Product Name |
Information |
| PC-24682 |
CD73 inhibitor XC-12
CD73 inhibitor
|
CD73 inhibitor XC-12 is a potent, orally bioactive CD73 inhibitor with IC50 of 12.36 and 1.29 nM against both soluble and membrane-bound forms (hCD73). |
| PC-24677 |
GT-02216
GCase modulator
|
GT-02216 is a novel allosteric glucocerebrosidase (GCase) modulator with binding KD of 55 uM, enhances GCase activity in primary human fibroblasts, prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models. |
| PC-24676 |
Limocitrin
CAS 489-33-8
|
Limocitrin is a natural hydroxyflavan with anticancer activity against breast cancer and NK leukemia cell lines, induceds cellular death through ERK pathways in human oral squamous cell cancer. |
| PC-24670 |
PF-07853578
PNPLA3 I148M degrader
|
PF-07853578 is a covalent inhibitor of patatin-like phospholipase domain-containing protein 3 single nucleotide polymorphism rs738409 148M (PNPLA3-148M), induces PNPLA3 degradation with EC50 of 8 nM. |
| PC-24661 |
Core Circadian Modulator
BMAL1 ligand
|
Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1–CLOCK target gene expressions. |
| PC-24660 |
Lipoamide
CAS 940-69-2
|
Lipoamide (Alpha-lipoamide) is a neutral derivative of lipoic acid with antioxidant and organ-protective properties, specifically prevents cytoplasmic condensation of stress granule proteins including SRSF1 and SFPQ. |
| PC-24652 |
hCES2A inhibitor 9d
hCES2A inhibitor
|
hCES2A inhibitor 9d is a potent, selective and covalent human carboxylesterase 2A (hCES2A) inhibitor with IC50 of 0.12 nM and Ki of 0.43 nM. |
| PC-24651 |
LC-20W
hCES2A inhibitor
|
LC-20W is potent, reversible human carboxylesterase 2A (hCES2A) inhibitor with IC50 of 1.6 nM. |
| PC-24650 |
Cucurbitacin B
IGF2BP1 inhibitor
|
Cucurbitacin B (CuB) is a potent but toxic anticancer natural product, an irreversible covalent inhibitor of IGF2BP1 and forms a covalent bond with cysteine 253 of the IGF2BP1 KH 1-2 domain (KD=66.8 nM). |
| PC-24649 |
IGF2BP1 inhibitor A11
IGF2BP1 inhibitor
|
IGF2BP1 inhibitor A11 is a specific small molecule insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) inhibitor, binds to IGF2BP) protein with KD of 2.88 nM. |
| PC-24648 |
DB2115 tertahydrochloride
PU.1 inhibitor
|
DB2115 tertahydrochloride is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM. |
| PC-24627 |
HSD17B13 inhibitor 32
HSD17B13 inhibitor
|
HSD17B13 inhibitor 32 is a highly potent, selective and liver-targeting HSD17B13 inhibitor with IC50 of 2.5 nM. |
