| Cat. No. |
Product Name |
Information |
| PC-25436 |
TREM2 agonist As48
TREM2 agonist
|
TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis. |
| PC-25434 |
KDS12025
Hb pseudoperoxidase enhancer
|
KDS12025 is a specific, BBB-permeable small molecule that enhances hemoglobin (Hb) pseudoperoxidase activity 100-fold (EC50=0.04 uM), enabling effective H2O2 decomposition even at extremely low Hb levels. |
| PC-25426 |
ARN398
Acid ceramidase inhibitor
|
ARN398 is a higly potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 7 nM and 12 nM for human and rat ACDase respectively, >100-fold selective over human thymidylate synthase (h-TS). |
| PC-25425 |
ARN14988
Acid ceramidase inhibitor
|
ARN14988 is a potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 12.8 nM. |
| PC-25424 |
Pepstatin A
Aspartic protease inhibitor
|
Pepstatin A (Pepstatin) is a potent, specific, orally active aspartic protease inhibitor with IC50 of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. |
| PC-25387 |
5-O-Methylvisammioside
HMGB1 inhibitor, CNT2 inhibitor
|
5-O-Methylvisammioside (5OMV) is a flavonol compound derived from the traditional Chinese medicine plant Saposhnikovia divaricat, inhibits vasospasm induced by High Mobility Group Box 1 (HMGB1) protein, also inhibits intestinal concentrative nucleoside transporter 2 (CNT2) with IC50 of 11.22 uM, inhibits intestinal purine nucleoside absorption. |
| PC-25386 |
Ceranib-2
Ceramidase inhibitor
|
Ceranib-2 (Ceranib 2) is a small molecule ceramidase inhibitor with IC50 of 28 uM in cell-based assays, exhibits antiproliferative effect in SKOV3 cells with IC50 of 0.71 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. |
| PC-25385 |
Ceranib-1
Ceramidase inhibitor
|
Ceranib-1 (Ceranib 1) is a small molecule ceramidase inhibitor, exhibits antiproliferative effect in SKOV3 cells with IC50 of 4.1 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. |
| PC-25384 |
Acid ceramidase inhibitor 43
Acid ceramidase inhibitor
|
Acid ceramidase inhibitor 43 is a potent, small molecule inhibitor of acid ceramidase (aCDase) with enzymatic pIC50 of 8.5 and cellular pIC50 of 6.8 (A375 melanoma cell). |
| PC-25362 |
Dracorhodin perchlorate
CD147 inhibitor
|
Dracorhodin perchlorate is a potent CD147 inhibitor that induces autophagy-dependent degradation, triggers PUFA/MUFA balance-mediated ferroptosis. |
| PC-25357 |
Avicularin
FOXM1 inhibitor
|
Avicularin is a Chinese herbal medicine with anti-inflammatory and antioxidative effects, reduces cell viability and induces caspase-dependent apoptosis in NSCLC cells by facilitating USP7-dependent degradation of FOXM1. |
| PC-25349 |
hClpP inhibitor TG42
hClpP inhibitor
|
hClpP inhibitor TG42 is a potent and selective inhibitor of hClpP with IC50 of 0.39 uM, efficiently blocks proteolysis. |
