| Cat. No. |
Product Name |
Information |
| PC-25741 |
SB-633825
TIE2 inhibitor, STK10 inhibitor
|
SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively, inhibits cancer cell growth and angiogenesis. |
| PC-25740 |
STK10 inhibitor 23
STK10 inhibitor
|
STK10 inhibitor 23 is a potent, selective inhibitor of STK10 (serine/threonine kinase 10, LOK) with IC50 of 0.85 uM. |
| PC-25732 |
RUVBL1/2 ATPase-IN-1
RUVBL1/RUVBL2 inhibitor
|
RUVBL1/2 ATPase-IN-1 is a small-molecule inhibitor of RUVBL1/2 ATPase with IC50 of 6.0 uM and 7.7 uM against RUVBL1/2 complex and RUVBL1 respectively. |
| PC-25731 |
RUVBL1/RUVBL2 inhibitor Compound B
RUVBL1/RUVBL2 inhibitor
|
RUVBL1/RUVBL2 inhibitor Compound B is a potent, specific and orally bioavailable RUVBL1/2 ATPase (pontin/TIP49 and reptin/TIP48) inhibitor with IC50 of 59 nM. |
| PC-25725 |
PYCR1-IN-1
PYCR1 inhibitor
|
PYCR1-IN-1 (ProPI-1, Proline Production Inhibitor-1) is a small molecule pyrroline-5-carboxylate reductase 1 (PYCR1) inhihibitor with IC50 of 8.8 uM. |
| PC-25712 |
RWT9996
GPR17 antagonist
|
RWT9996 is a potent, selective GPR17 antagonist, inhibits both G protein activation and β-arrestin-2 recruitment. |
| PC-25706 |
hCES2A inhibitor C3
hCES2A inhibitor
|
hCES2A inhibitor C3 is a highly potent, orally active and serine-targeting covalent inhibitor of hCES2A (human carboxylesterase 2A) with IC50 of 0.56 nM, Ki of 1.58 nM. |
| PC-25702 |
ARN14686
NAAA probe
|
ARN14686 is a click chemistry activity-based probe (CC-ABP) that selectively recognizes the enzyme N-acylethanolamine acid amidase (NAAA). |
| PC-25694 |
Auxurea A
GH3 inhibitor
|
Auxurea A is a selective competitive small molecule inhibitor of IAA-amino acid conjugating enzymes GH3, specifically inhibited GH3-mediated IAA inactivation both in vivo and in vitro, induces high-auxin phenotypes in Arabidopsis. |
| PC-25661 |
TDRL-505
RPA inhibitor
|
TDRL-505 is a small molecule inhibitor of Replication protein A (RPA) with IC50 of 13 uM, inhibits RPA's DNA binding activity targeting DBD-A and B in the 70 kDa subunit of RPA. |
| PC-25635 |
TTZ-2
zDHHC2 inhibitor
|
TTZ-2 (zDHHC2 inhibitor TTZ2) is a specific enzymatic inhibitor of ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 1.3 uM. |
| PC-25612 |
W478
SHMT2 inhibitor
|
W478 is a potent novel serine hydroxymethyltransferase 2 (SHMT2) inhibitor with IC50 of 1.21 uM, binds to SHMT2 with ITC KD of 10.6 uM. |
