| Cat. No. |
Product Name |
Information |
| PC-25558 |
KCB3602
Lin28-let-7 inhibitor
|
KCB3602 is a specific small-molecule inhibitor of the Lin28–let-7 interaction with IC50 of 4.8 uM in EMSA assays, shows direct binding to Lin28a with SPR KD of 5.9 uM. |
| PC-25556 |
α-difluoromethylornithine
Ornithine decarboxylase inhibitor
|
α-difluoromethylornithine (DFMO, Eflornithine, MDL71782) is a specific, irreversible inhibitor of polyamine biosynthesis enzyme Ornithine decarboxylase (ODC) with biochemicals IC50 of 252 uM, binding competitively with ornithine. |
| PC-25540 |
Ezurpimtrostat hydrochloride
PPT1 inhibitor
|
Ezurpimtrostat hydrochloride (GNS561) is a novel lysosomotropic agent and autophagy inhibitor that induces lysosomal cell death, targets palmitoyl-protein thioesterase 1 (PPT1). |
| PC-25528 |
MDOLL-0286
ARH3 inhibitor
|
MDOLL-0286 is a potent and selective inhibitor for ADP-ribosylhydrolase 3 (ARH3) with IC50 of 2.3 uM, selective against closely related homologues ARH1. |
| PC-25526 |
MSC778
FEN1 inhibitor
|
MSC778 (MSC-778) is a potent, selective, and orally bioavailable inhibitor of Flap endonuclease 1 (FEN1) with IC50 of 3.0 nM and SPR KD of 2.9 nM, >65-fold selective over closely related RAD2 family members EXO1, GEN1 and XPG. |
| PC-25516 |
iOXCT1
OXCT1 inhibitor
|
iOXCT1 (D574-0246) is a specific small molecule 3-Oxoacid CoA-transferase 1 (OXCT1) inhibitor, inhibits the dual enzymatic ketolytic and succinyltransferase activities of OXCT1 specifically. |
| PC-25481 |
W1122
SNX3 inhibitor
|
W1122 is a specific small-molecule inhibitor of Sorting nexin 3 (SNX3). |
| PC-25466 |
MASTL inhibitor MKI-2
Greatwall inhibitor
|
MKI-2 (MASTL kinase inhibitor-2) is a potent small molecule inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall/GWL), inhibits recombinant MASTL activity and cellular MASTL activity with IC50 of 37.44 nM and 142.7 nM, respectively. |
| PC-25465 |
Greatwall inhibitor C-604
Greatwall inhibitor
|
Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays. |
| PC-25458 |
DH20931
CerS2 agonist
|
DH20931 is a first-in-class, potent small-molecule agonist of Ceramide Synthase 2 (CerS2) with activation constant (Kact) of 16.54 nM, exhibits potent, broad-spectrum, and receptor-independent antitumor activity in vitro and in vivo. |
| PC-25450 |
RTI-19318-32
GPR3 agonist
|
RTI-19318-32 is a potent, specific full agonist of G protein-coupled receptor 3 (GPR3) with EC50 of 260 nM and Emax of 90%. |
| PC-25446 |
G4451
GPR31 inhibitor
|
G4451 is a specific small molecule inhibitor of GPR31, inhibits the GPR31-Gαi3 interaction by targeting the GPR31 conformational transition, effectively blocked MASH progression. |
