| Cat. No. |
Product Name |
Information |
| PC-24450 |
SMS2 inhibitor Ly93
SMS2 inhibitor
|
SMS2 inhibitor Ly93 is a potent, selective, orally efficacious sphingomyelin synthase 2 (SMS2) inhibitor with IC50 of 91 nM, >1000-fold selective over SMS1, demonstrates anti-atherosclerotic activities in vivo. |
| PC-24449 |
SMS2 inhibitor 14l
SMS2 inhibitor
|
SMS2 inhibitor 14l is a highly potent and selective sphingomyelin synthase 2 (SMS2) inhibitor with IC50 of 28 nM (sphingomyelin (SM) synthesis), with no activity against SMS1 (IC50=16 uM). |
| PC-24446 |
DCLK1 inhibitor a24
DCLK1 inhibitor
|
DCLK1 inhibitor a24 is an effective inhibitor of doublecortin-like kinase 1 (DCLK1) with IC50 of 179.7 nM, KD of 2.12 uM. |
| PC-24394 |
BCT1028
BLVRB inhibitor
|
BCT1028 is a potent, selective small molecule Biliverdin IXβ reductase (BLVRB) inhibitor with IC50 of 195 nM (50 uM BLVRB substrate DCPIP). |
| PC-24387 |
TMQ0153
OPA1 inhibitor, Necrosis inducer
|
TMQ0153 (TMQ153) is a tetrahydrobenzimidazole derivative with cytotoxic potential against hematopoietic cancer cell lines, targets mitochondrial dynamics by inhibiting mitochondrial fusion protein optic atrophy 1 (OPA1), inducing metabolic reprogramming, and triggering apoptosis in AML cells. |
| PC-24382 |
MitoSNO
Mitochondria S-nitrosating agent
|
MitoSNO (mitochondria-targeted S-nitrosothiol) is a mitochondria-selective S-nitrosating agent, selectively S-nitrosates mitochondrial proteins. |
| PC-24362 |
BMS-250
MPO inhibitor
|
BMS-250 is a potent, selective and reversible inhibitor of myeloperoxidase (MPO) with IC50 of 13 nM, Patent WO2017040449. |
| PC-24361 |
SNT-8370
VAP-1/MPO inhibitor
|
SNT-8370 is a potent, selective and irreversible dual inhibitor targeting vascular adhesion protein-1 (VAP-1) and myeloperoxidase (MPO) with IC50 of 10 nM and 17 nM respectively. |
| PC-24358 |
JM-20
Neuroprotective agent
|
JM-20 is a benzodiazepine–dihydropyridine hybrid molecule, preventsPC-12 cell death induced either by glutamate, hydrogen peroxide or KCN-mediated chemical hypoxia, a multi-target neuroprotective agent. |
| PC-24321 |
SBDA
RCC2 inhibitor
|
SBDA is a small molecule inhibitor of RCC2 (TD-60) active pocket and specifically blocks RCC2 lactylation, inhibits breast cancer cell proliferation. |
| PC-24318 |
LPHN2 inhibitor D11
LPHN2 inhibitor
|
LPHN2 inhibitor D11 is a reversible and selective inhibitor of mechanosensitive GPCR latrophilin 2 (LPHN2, ADGRL2), inhibits mechanosensitivity of LPHN2 in HEK293 cells with IC50 of 20 nM. |
| PC-24316 |
Calycosin
PANoptosis inhibitor
|
Calycosin is a flavonoid compound derived from the root of Astragalus, alleviates ischemic stroke by inhibiting PANoptosis. |
