BMS-363131 | Tryptase inhibitor | Probechem Biochemicals

Chemical Structure : BMS-363131

BMS-363131 (BMS363131)

Catalog No.: PC-25175Not For Human Use, Lab Use Only.

BMS-363131 is a potent, selective inhibitor of tryptase with IC50 of <1.7 nM, having excellent selectivity versus other serine proteases including trypsin.

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Biological Activity

BMS-363131 is a potent, selective inhibitor of tryptase with IC50 of <1.7 nM, having excellent selectivity versus other serine proteases including trypsin.
BMS-363131 displays high selectivity (>3,000-fold) versus trypsin and >10,000-fold versus plasmin, thrombin, uPA, and tPA.
BMS-363131 is efficacious in a guinea pig model of asthma.

Physicochemical Properties

M.Wt	540.67
Formula	C28H40N6O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Azetidinecarboxylic acid, 3-[[(3R)-1-(aminoiminomethyl)-3-piperidinyl]methyl]-4-oxo-1-[[4-(1-oxo-6-phenylhexyl)-1-piperazinyl]carbonyl]-, (2S,3R)-

References

1. Slusarchyk WA, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3235-8.

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BMS-363131 (BMS363131)

Biological Activity

Physicochemical Properties

References

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