| Cat. No. |
Product Name |
Information |
| PC-45088 |
SP-420
Iron chelating agent
|
Petadeferitrin (SP-420) is a desferrithiocin analogue and iron chelating agent that has iron-clearing efficiency with ICE value of 26.7, SP-420 is more potent than desferrithiocin. |
| PC-42072 |
BAPTA
Mg2+ chelator
|
BAPTA is a cell-permeant, calcium-specific chelator with high selectivity over Mg2+. |
| PC-45623 |
GW4869
nSMase inhibitor
|
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM. |
| PC-42082 |
TPEN
LIN28 inhibitor
|
TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-24683 |
CD73-IN-1
CD73 inhibitor
|
CD73-IN-1 is a potent, selective CD73 (ecto-5'-nucleotidase) inhibitor. |
| PC-24682 |
CD73 inhibitor XC-12
CD73 inhibitor
|
CD73 inhibitor XC-12 is a potent, orally bioactive CD73 inhibitor with IC50 of 12.36 and 1.29 nM against both soluble and membrane-bound forms (hCD73). |
| PC-24677 |
GT-02216
GCase modulator
|
GT-02216 is a novel allosteric glucocerebrosidase (GCase) modulator with binding KD of 55 uM, enhances GCase activity in primary human fibroblasts, prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models. |
| PC-24676 |
Limocitrin
CAS 489-33-8
|
Limocitrin is a natural hydroxyflavan with anticancer activity against breast cancer and NK leukemia cell lines, induceds cellular death through ERK pathways in human oral squamous cell cancer. |
| PC-24670 |
PF-07853578
PNPLA3 I148M degrader
|
PF-07853578 is a covalent inhibitor of patatin-like phospholipase domain-containing protein 3 single nucleotide polymorphism rs738409 148M (PNPLA3-148M), induces PNPLA3 degradation with EC50 of 8 nM. |
| PC-24661 |
Core Circadian Modulator
BMAL1 ligand
|
Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1–CLOCK target gene expressions. |
| PC-24660 |
Lipoamide
CAS 940-69-2
|
Lipoamide (Alpha-lipoamide) is a neutral derivative of lipoic acid with antioxidant and organ-protective properties, specifically prevents cytoplasmic condensation of stress granule proteins including SRSF1 and SFPQ. |
