| Cat. No. |
Product Name |
Information |
| PC-23451 |
PF-07328948
BDK inhibitor
|
PF-07328948 is the first potent, selective branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK) with in vitro IC50 of 15 nM, and cellular IC50 of 46 nM in human skeletal muscle BDK activity assay. |
| PC-23450 |
UNC10142
CHD1 inhibitor
|
UNC10142 is a first-in-class, specific, cell-active small molecule antagonist of the tandem chromodomains of CHD1 (Chromodomain-Helicase DNA-Binding Protein 1) with binding IC50 of 1.7 uM in TR-FRET assays. |
| PC-23443 |
164A10
Pin1 degrader
|
164A10 is a potent Pin1 destabilizer and degrader with IC50 of 4.1 nM in DELFIA displacement assay, destabilizes Pin1 in vitro and also results more effective in causing Pin1 degradation in cells. |
| PC-23442 |
158H9
Pin1 degrader
|
158H9 is a potent Pin1 destabilizer and degrader with IC50 of 21.5 nM in DELFIA displacement assay, destabilizes Pin1 in vitro and also results more effective in causing Pin1 degradation in cells. |
| PC-23441 |
BJP-07-017-3
Pin1 inhibitor
|
BJP-07-017-3 is a potent, selective, covalent, cell-permeable peptide Pin1 inhibitor (Ki=15 nM), IC50 of 9 nM in DELFIA assays, covalently targets Cys113, a highly conserved cysteine located in the Pin1 active site. |
| PC-23439 |
KB-151
Phagocytosis inhibitor
|
KB-151 is a small molecule phagocytosis inhibitor with IC50 of 2.7 uM in human PBMCs, shows no significant toxicity. |
| PC-23438 |
KB-208
Phagocytosis inhibitor
|
KB-208 is a small molecule phagocytosis inhibitor with IC50 of 4.2 uM in human PBMCs, shows no significant toxicity. |
| PC-23404 |
NAC1 inhibitor NIC3
NAC1 inhibitor
|
NAC1 inhibitor NIC3 is a specific small molecule inhibitor of oncogenic nucleus accumbens-associated protein-1 (NAC1), inhibits NAC1 homodimerization, leading to proteasomal NAC1 degradation. |
| PC-23394 |
OGT 2115
Heparanase inhibitor
|
OGT 2115 is a potent, specific, cell-permeable and orally active heparanase inhibitor with IC50 of 0.4 uM, inhibits the expression and activity of heparanase. |
| PC-23379 |
BIM-46174
Heterotrimeric Gα/Gβγ inhibitor
|
BIM-46174 is a selective inhibitor of heterotrimeric G-protein complex Gα/Gβγ subunits, abrogates cancer cell invasion controlled by several GPCR agonists. |
| PC-23378 |
GQ262
Gαq/11 inhibitor
|
GQ262 is a small molecule Gαq/11 protein inhibitor with IC50 of <10 uM, inhibits MP41 cell proliferation with IC50 of 5.1 uM. |
| PC-23377 |
GQ127
Gαq/11 inhibitor
|
GQ127 is a potent, selective Gαq/11 signaling pathway inhibitor with IC50 of 22.4 uM. GQ127 shows good efficacy and safety in inositol monophosphate (IP1) assay by directly inhibiting Gαq/11 proteins. |
