| Cat. No. |
Product Name |
Information |
| PC-23053 |
Vamagloxistat
Glycolate oxidase inhibitor
|
Vamagloxistat (BBP-711) is a small molecule inhibitor of glycolate oxidase (GOX, GO) for primary hyperoxaluria type 1 and recurrent kidney stone formers. |
| PC-23045 |
EN300
GPRC6A agonist
|
EN300 is a small ligand agonist for GPRC6A, stimulates ERK phosphorylation and cAMP accumulation with EC50 of 2.331 and 3.448 mM, respectively. |
| PC-23025 |
GSDMD agonist DMB
Gasdermin D agonist
|
GSDMD agonist DMB is a direct and selective gasdermin D (GSDMD) agonist, activates GSDMD pore formation to trigger liposome leakage with EC50 of 0.7 uM, activates GSDMD pore formation and pyroptosis without cleaving GSDMD. |
| PC-23021 |
SRSF10 inhibitor 1C8
SRSF10 inhibitor
|
SRSF10 inhibitor 1C8 is a specific small molecule inhibitor of SRSF1, alters splicing regulation mediated by SRSF10, shows strong anti-HIV-1 potency against a variety of clinical strains in vitro. |
| PC-23018 |
Aulosirazole
FOXO3a modulator
|
Aulosirazole, an isothiazolonaphthoquinone alkaloid, shows cytotoxic activity against OVCAR3 cells (IC50=301 nM), promotes forkhead box O3a (FOXO3a) nuclear accumulation and modulates downstream targets. |
| PC-22980 |
Peptide SBT-20
ROS-lowering peptide
|
Peptide SBT-20 (SS-20) is a cell-permeable peptide targeting the inner mitochondrial membrane, reduces ROS, normalizes electron transport chain function and ATP generation. |
| PC-22978 |
Peptide NAPLVHATL
KIR2DS2 ligand
|
Peptide NAPLVHATL is an XPO1-derived peptide and a ligand for KIR2DS2, can be recognized by the activating NK cell receptor KIR2DS2 in the context of human leukocyte antigen-C. |
| PC-22965 |
KHK inhibitor 14
Ketohexokinase inhibitor
|
KHK inhibitor 14 is a potent ketohexokinase (KHK) inhibitor with IC50 of 59 nM for KHK-A enzymatic assay and IC50 of 196 nM for hepG2 assay. |
| PC-22964 |
BI-9787
Ketohexokinase inhibitor
|
BI-9787 is a potent, selective zwitterionic ketohexokinase (KHK) inhibitor with enzymatic IC50 of 12/12.8 nM (hKHK-A/C), and cellular IC50 of 123 nM in F1P HepG2 assay. |
| PC-22962 |
ABCA1 inducer 39
ABCA1 inducer
|
ABCA1 inducer 39 is a nonlipogenic ABCA1-inducer (NLAI) with EC50 of 0.1 uM, increases ABCA1 expression, enhances APOE lipidation, and reverses multiple AD phenotypes, without increasing triglycerides (TG). |
| PC-22918 |
NAT1 inhibitor Cmp350
NAT1 inhibitor
|
NAT1 inhibitor Cmp350 is a potent small molecule inhibitor of arylamine N-acetyltransferase 1 (NAT1) with IC50 of 44 nM, inhibits mitochondrial respiration and alters mitochondrial metabolism in MDA-MB-231 cells. |
| PC-22916 |
hSR inhibitor 28
Serine racemase inhibitor
|
hSR inhibitor 28 is a potent, selective inhibitor of human serine racemase (SR) with Kd of 5 uM. |
