Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TK216
CAS No.: 1903783-48-1
Catalog No.: PC-61994Not For Human Use, Lab Use Only.
TK216 is a first in class, small molecule that directly binds EWS-FLI1 inhibiting the biological activity of ETS-family transcription factor oncoproteins and is currently under clinical investigation against Ewing sarcoma..
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TK216 is a first in class, small molecule that directly binds EWS-FLI1 inhibiting the biological activity of ETS-family transcription factor oncoproteins and is currently under clinical investigation against Ewing sarcoma.
TK216 acts as an microtubule destabilizing agent, exhibits anti-cancer activity against cancer cell lines and xenografts that do not express EWSR1-FLI1.
| M.Wt | 376.233 | |
| Formula | C19H15Cl2NO3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4,7-dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one |
|
1, Filippo Spriano, et al. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
