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TK216

Chemical Structure : TK216

CAS No.: 1903783-48-1

TK216 (TK 216, TK-216)

Catalog No.: PC-61994Not For Human Use, Lab Use Only.

TK216 is a first in class, small molecule that directly binds EWS-FLI1 inhibiting the biological activity of ETS-family transcription factor oncoproteins and is currently under clinical investigation against Ewing sarcoma..

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Biological Activity

TK216 is a first in class, small molecule that directly binds EWS-FLI1 inhibiting the biological activity of ETS-family transcription factor oncoproteins and is currently under clinical investigation against Ewing sarcoma.
TK216 acts as an microtubule destabilizing agent, exhibits anti-cancer activity against cancer cell lines and xenografts that do not express EWSR1-FLI1.

Physicochemical Properties

M.Wt 376.233
Formula C19H15Cl2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4,7-dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one

References

1, Filippo Spriano, et al. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176.

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