Chemical Structure : NS-3-008
CAS No.: 1172854-54-4
Catalog No.: PC-61825Not For Human Use, Lab Use Only.
NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM.
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NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM.
NS-3-008 decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.).
NS-3-008 decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD).
M.Wt | 269.817 | |
Formula | C14H24ClN3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1-benzyl-3-hexylguanidine hydrochloride |
1. Matsunaga N, et al. EBioMedicine. 2016 Nov;13:262-273.
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