NS-3-008 |CAS:1172854-54-4 Probechem Biochemicals

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Chemical Structure : NS-3-008

CAS No.: 1172854-54-4

NS-3-008 (G0/G1 switch 2 inhibitor)

Catalog No.: PC-61825Not For Human Use, Lab Use Only.

NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM.

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10 mg	$98	In stock
25 mg	$158	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM.
NS-3-008 decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.).
NS-3-008 decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD).

Physicochemical Properties

M.Wt	269.817
Formula	C14H24ClN3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-3-hexylguanidine hydrochloride

References

1. Matsunaga N, et al. EBioMedicine. 2016 Nov;13:262-273.

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NS-3-008 (G0/G1 switch 2 inhibitor)

Biological Activity

Physicochemical Properties

References

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