LCS-1.28 |CAS:1035450-90-8 Probechem Biochemicals

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Chemical Structure : LCS-1.28

LCS-1.28 (LCS1.28)

Catalog No.: PC-62032Not For Human Use, Lab Use Only.

LCS-1.28 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.05-1.6 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LCS-1.28 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.05-1.6 uM.
Superoxide dismutase 1 (SOD1) is the most likely target.
LCS-1.28 inhibits SOD1 in a dose-dependent manner with IC50 of 0.95 uM.

Physicochemical Properties

M.Wt	344.006
Formula	C11H8Br2N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,5-dibromo-2-m-tolylpyridazin-3(2H)-one

References

1. Somwar R, et al. J Biomol Screen. 2009 Dec;14(10):1176-84.

2. Somwar R, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80.

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LCS-1.28 (LCS1.28)

Biological Activity

Physicochemical Properties

References

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