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Trofinetide

Chemical Structure : Trofinetide

CAS No.: 853400-76-7

Trofinetide (NNZ 2566, NNZ2566)

Catalog No.: PC-61796Not For Human Use, Lab Use Only.

Trofinetide (NNZ 2566) is a peptidomimetic tripeptide Gly-Pro-Glu that has anti-inflammatory and neuroprotective properties against hypoxic-ischemic brain injury and neurodegeneration.

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Biological Activity

Trofinetide (NNZ 2566) is a peptidomimetic tripeptide Gly-Pro-Glu that has anti-inflammatory and neuroprotective properties against hypoxic-ischemic brain injury and neurodegeneration.
Trofinetide (NNZ 2566) improves functional recovery and attenuates apoptosis and inflammation in a rat model of penetrating ballistic-type brain injury.
Trofinetide (NNZ 2566) significantly reduces injury-mediated up-regulation of IL-1beta, TNF-alpha, E-selectin and IL-6 mRNA in the injured brain in rats.

Physicochemical Properties

M.Wt 315.322
Formula C13H21N3O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

((S)-1-glycyl-2-methylpyrrolidine-2-carbonyl)-L-glutamic acid

References

1. Bickerdike MJ, et al. J Neurol Sci. 2009 Mar 15;278(1-2):85-90.

2. Lu XC, et al. J Cereb Blood Flow Metab. 2009 Dec;29(12):1924-32.

3. Wei HH, et al. J Neuroinflammation. 2009 Aug 5;6:19.

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