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Chemical Structure : LCS-1
CAS No.: 41931-13-9
Catalog No.: PC-62031Not For Human Use, Lab Use Only.
LCS-1 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.1-1.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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LCS-1 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.1-1.5 uM.
Superoxide dismutase 1 (SOD1) is the most likely target of LCS-1, LCS-1 inhibits SOD1 in a dose-dependent manner with IC50 of 1.07 uM.
SOD1 is an LCS-1-binding protein that may act in concert with mutant proteins, such as EGFR and KRAS, to promote cell growth.
| M.Wt | 255.098 | |
| Formula | C11H8Cl2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4,5-dichloro-2-m-tolylpyridazin-3(2H)-one |
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1. Somwar R, et al. J Biomol Screen. 2009 Dec;14(10):1176-84.
2. Somwar R, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80.
3. Sajesh BV, et al. Oncotarget. 2015 Sep 29;6(29):27907-22.
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