LCS-1 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.1-1.5 uM.
Superoxide dismutase 1 (SOD1) is the most likely target of LCS-1, LCS-1 inhibits SOD1 in a dose-dependent manner with IC50 of 1.07 uM.
SOD1 is an LCS-1-binding protein that may act in concert with mutant proteins, such as EGFR and KRAS, to promote cell growth.
Physicochemical Properties
M.Wt
255.098
Formula
C11H8Cl2N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4,5-dichloro-2-m-tolylpyridazin-3(2H)-one
References
1. Somwar R, et al. J Biomol Screen. 2009 Dec;14(10):1176-84.
2. Somwar R, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80.
3. Sajesh BV, et al. Oncotarget. 2015 Sep 29;6(29):27907-22.
