| Cat. No. |
Product Name |
Information |
| PC-26323 |
Dinifedriton
Mitochondrial uncoupler
|
Dinifedriton is a small molecule mitochondrial uncoupler for regulating mitochondria activity and reducing adiposity in the treatment of diseases. |
| PC-26317 |
VRK-IN-1
VRK1/VRK2 inhibitor
|
VRK-IN-1 is a potent, selective inhibitor of Vaccinia-related kinases 1 and 2 (VRK1 and VRK2) with ITC KD values of 190 nM and 401 nM, IC50 of 150 nM (VRK1). |
| PC-26316 |
VRK1 inhibitor Compound 1
VRK1 inhibitor
|
VRK1 inhibitor Compound 1 (VRK1-IN-1) is a potent, selective and ATP-competitive inhibitor of Vaccinia-related kinase 1 (VRK1) with Ki of 82 nM and IC50 of 154 nM, selective for VRK1 over VRK2. |
| PC-26308 |
GIT1/β-Pix inhibitor 14-5-18
GIT1/β-Pix inhibitor
|
GIT1/β-Pix inhibitor 14-5-18 is a small-molecule inhibitor to interrupt the protein–protein interaction (PPI) of GIT1/β-Pix complex with Ki of 1.8 uM in FP assays, directly binds to GIT1 with BLI KD of 7.7 uM, inhibits gastric cancer metastasis. |
| PC-26306 |
GIT1 inhibitor Compound 3
GIT1 inhibitor
|
GIT1 inhibitor Compound 3 (GIT1-IN-C3) is a selective small molecule inhibitor of ARF GTPase protein 1 (GIT1) with MST KD of 6.2 uM, effectively disrupts GIT1 from interacting with MAT2B and RAF/MEK/ERK to halt cancer cell growth in vitro and in vivo. |
| PC-26292 |
STK189682
RNA helicase inhibitor
|
STK189682 is a potent small molecule inhibitor of RNA helicases MDA5, LGP2, and DDX1 with IC50 of 7 uM, 7 uM and 5 uM in ATPase assays. |
| PC-26275 |
Rebaudioside N
SBK2 agonist
|
Rebaudioside N is a terpenoid glycoside isolated from the leaves of Stevia rebaudiana Bertoni, is a potent SH3 domain-binding kinase 2 (SBK2) agonist, effectively suppresses NLRP3-mediated IL-1β/IL-18 secretion, reduces inflammatory responses, and diminishes atherosclerotic burden. |
| PC-26272 |
CZ-2401
TRIM47-HNF4α inhibitor
|
CZ-2401 is a potent, specific inhibitor of the TRIM47-HNF4α interaction, binds to HNF4α with MST Kd of 2.52 uM, stabilizes HNF4α protein and activates HNF4α transcriptional activity. |
| PC-26260 |
Bufotalin
COL1A1 inhibitor
|
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities, a selective and potent inhibitor of COL1A1-high NSCLC. |
| PC-26246 |
Carbutamide
339-43-5
|
Carbutamide (BZ-55) is Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity. |
| PC-26216 |
Furin inhibitor 9
Furin inhibitor
|
Furin inhibitor 9 is a highly potent, small molecule inhibitor of proprotein convertase (PC) furin with Ki of 12.4 nM, weakly inhibits the structurally related PC7 with Ki of 278 nM, shows antiviral potency against the furin-dependent H7N7 influenza A strain SC35M. |
| PC-26215 |
Furin inhibitor 27
Furin inhibitor
|
Furin inhibitor 27 is a highly potent, small molecule inhibitor of proprotein convertase (PC) furin with Ki of 1.67 nM, also inhibits the structurally related PC7 with Ki of 7.27 nM. |
