| Cat. No. |
Product Name |
Information |
| PC-49386 |
S9-A13
SLC26A9 inhibitor
|
S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively. |
| PC-49384 |
DKC1125
KITENIN inhibitor
|
DKC1125 is a small molecule KSRP-binding compound that specifically inhibits the oncogenic KITENIN complex, suppresses distant metastasis of colorectal cancer (CRC). |
| PC-49379 |
BDK inhibitor BT3
BCKDC kinase inhibitor
|
BDK inhibitor BT3 is a small molecule allosteric inhibitor of BCKDC kinase (BDK). |
| PC-49378 |
BDK inhibitor BT2
BCKDC kinase inhibitor
|
BDK inhibitor BT2 is a small molecule allosteric inhibitor of BCKDC kinase (BDK) with IC50 of 3.19 uM. |
| PC-49370 |
GCN2 inhibitor 39
GCN2 inhibitor
|
GCN2 inhibitor 39 is a highly potent and selective, orally active inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 5 nM. |
| PC-49336 |
JBSNF-000028
NNMT inhibitor
|
JBSNF-000028 (JBSNF000028) is a potent, selective, orally bioavailable substrate-analog inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 of 34 nM, 190 and 210 nM against human, monkey and mouse NNMT, respectively. |
| PC-49332 |
4-Sulfocalix[8]arene hydrate
AIM2 inhibitor
|
4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
| PC-49331 |
4-Sulfocalix[6]arene hydrate
AIM2 inhibitor
|
4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
| PC-49318 |
TK106
SARM1 inhibitor
|
TK106 is a small molecule non-competitive inhibitor of hSARM1 with IC50 of 10.8 uM, induces and promotes the formation of SARM1 octamers. |
| PC-49281 |
IL17A inhibitor 10
IL17A inhibitor
|
IL17A inhibitor 10 is a potent and selective, cell-active inhibitor of IL17A C-terminal region with high binding affinity (SPR KD=43 nM), shows inhibition of IL17A/IL7RA-Fc interactions with IC50 of 740 nM. |
| PC-49279 |
RUNX1/ETO inhibitor 7.44
RUNX1-ETO inhibitor
|
RUNX1-ETO inhibitor 7.44 is a first-in-class, small-molecule inhibitor of RUNX1/ETO tetramerization, specifically interferes the nervy homology region 2 (NHR2) domain of ETO mediating tetramerization with Klig value of 3.75 uM. |
| PC-49272 |
CRS0540
PolC inhibitor
|
CRS0540 is a potent, selective PolC DNA polymerase inhibitor that has demonstrated good in vitro and in vivo activity against Listeria monocytogenes. |
