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EG1

Chemical Structure : EG1

CAS No.: 693241-54-2

EG1 (Pax2 inhibitor EG1)

Catalog No.: PC-62416Not For Human Use, Lab Use Only.

Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM.

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Biological Activity

Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM.
EG1 inhibits Pax2 mediated expression with IC50 of 10 uM, and inhibits proliferation of Pax2 positive renal and ovarian cancer cell lines but has little effect on Pax2 negative cancer cells.
EG1 inhibits embryonic kidney development.

Physicochemical Properties

M.Wt 390.395
Formula C22H18N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4-(2-methoxybenzamido)benzamido)benzoic acid

References

1. Grimley E, et al. ACS Chem Biol. 2017 Mar 17;12(3):724-734.

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