CSIC E379

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Chemical Structure : CSIC E379

Catalog No.: PC-62437Not For Human Use, Lab Use Only.

CSIC E379 is a potent, selective uncoupling proteins UCP1/UCP2 inhibitor with EC50 of 20 uM/30 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CSIC E379 is a potent, selective uncoupling proteins UCP1/UCP2 inhibitor with EC50 of 20 uM/30 uM, respectively.
CSIC E379 does not affect OXPHOS system and membrane permeability in liver mitochondria.
CSIC E379 causes oxidative stress, inhibit the cellular respiration of the cancer cell line HT-29.
CSIC E379 increases the production of superoxide and decreases the cell viability.
CSIC E379 potentiates the efficacy of the cytotoxic drug arsenic trioxide.

Physicochemical Properties

M.Wt	280.411
Formula	C20H24O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-isopropyl-2,2-dimethyl-6-phenylchromane

References

1. Rial E, et al. Chem Biol. 2011 Feb 25;18(2):264-74.

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CSIC E379

Biological Activity

Physicochemical Properties

References

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