Cat. No. |
Product Name |
Information |
PC-49726 |
Seletracetam
SV2A ligand
|
Seletracetam (ucb 44212) is a high affinity for the synaptic vesicle protein 2A (SV2A) than levetiracetam with 10-fold, exhibits anticonvulsant properties in animal models of epilepsy. |
PC-49704 |
NUP-17d-52A
Plek2 inhibitor
|
NUP-17d-52A (Plek2 inhibitor) is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2-DEP domain with high affinity (Kd=160 nM). |
PC-49703 |
Plek2 inhibitor NUP-17d
Plek2 inhibitor
|
Plek2 inhibitor NUP-17d is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2 and Plek2-DEP with high affinity (ITC KD=109 and 350 nM, respectively). |
PC-49693 |
Xist inhibitor X1
Xist inhibitor
|
Xist inhibitor X1 is a selective small molecule inhibitor of the non-coding RNA prototype Xist function, binds specifically to the RepA motif of Xist (Kd=0.4 uM) in vitro and in vivo. |
PC-49690 |
Novobiocin
POLθ inhibitor
|
Novobiocin (NVB) is a potent, specific DNA polymerase theta (POLθ, POLQ) inhibitor with IC50 of 24 uM, selectively kills HR-deficient tumor cells in vitro and in vivo. |
PC-49685 |
MPO inhibitor IN-4
MPO inhibitor
|
MPO inhibitor IN-4 is a highly potent, selective, irreversible and orally bioavailable myeloperoxidase (MPO) inhibitor. |
PC-49680 |
ART899
DNA Polθ inhibitor
|
ART899 (ART-899) is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM, shows with improved in vivo stability compared to ART558. |
PC-49648 |
FK3453
TSLP inhibitor
|
FK3453 (FK 3453) is a novel inhibitor of thymic stromal lymphopoietin (TSLP) production, reduces both TSLP protein levels and mRNA levels both in vitro and in vivo. |
PC-49645 |
TH8535
OGG1 inhibitor
|
TH8535 (TH-8535) is a potent, selective inhibitor of 8-oxo Guanine DNA Glycosylase 1 (OGG1) with IC50 of 0.2 uM. |
PC-49631 |
Brivaracetam
SV2A ligand
|
Brivaracetam (UCB 34714) is a potent, selective synaptic vesicle protein 2A (SV2A) ligand with pKi of 6.5, 20-fold more potent than Levetiracetam (Cat# PC49630), shows anticonvulsant activities in audiogenic mice. |
PC-49630 |
Levetiracetam
SV2A ligand
|
Levetiracetam (UCB L059) an antiepileptic drug with a unique activity profile in animal models of seizure and epilepsy, binds to (pKi=5.2) and modulates synaptic vesicle protein SV2A. |
PC-49607 |
NCP26
ProRS inhibitor
|
NCP26 is a potent, ATP-competitive prolyl-tRNA synthetase (ProRS, PRS) inhibitor, inhibits recombinant human ProRS in the presence of 100 μM proline with KD of 0.35 nM in TR-FRET assays. |