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PF-6808472

Chemical Structure : PF-6808472

CAS No.: 2088112-70-1

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PF-6808472 (XO44)

Catalog No.: PC-62860Not For Human Use, Lab Use Only.

PF-6808472 (XO44) is a sulfonyl fluoride chemical probe that covalently labels a broad swath of the intracellular kinome with high efficiency.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-6808472 (XO44) is a sulfonyl fluoride chemical probe that covalently labels a broad swath of the intracellular kinome with high efficiency.
    PF-6808472 (XO44) covalently modifies up to 133 endogenous kinases, efficiently competes with high intracellular concentrations of ATP.
    PF-6808472 (XO44) an useful tool in demanding chemoproteomic applications.

    Physicochemical Properties

    M.Wt 538.602
    Formula C25H27FN8O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-{4-[4-(5-Cyclopropyl-1H-pyrazol-3-ylamino)-6-prop-2-ynylcarbamoyl-pyrimidin-2-yl]-piperazin-1-ylmethyl}-benzenesulfonyl fluoride

    References

    1. Zhao Q, et al. J Am Chem Soc. 2017 Jan 18;139(2):680-685.

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