VU6001221 | Choline transporter inhibitor

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Chemical Structure : VU6001221

VU6001221 (VU 6001221)

Catalog No.: PC-62786Not For Human Use, Lab Use Only.

VU6001221 is a potent choline transporter (CHT) inhibitor with IC50 of 270 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU6001221 is a potent choline transporter (CHT) inhibitor with IC50 of 270 nM.
VU6001221 shows comparable potency for choline uptake inhibition as ML352, yet improved PK and CNS penetration.
VU6001221 elicits a dose-responsive increase in NOR, raises the possibility of agonism of synaptic α7 nicotinic ACh receptors by elevated extracellular choline.

Physicochemical Properties

M.Wt	391.89
Formula	C20H26ClN3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 4-chloro-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3 -[(1-methyl-4-piperidinyl)oxy]-

References

1. Bertron JL, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-40.

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VU6001221 (VU 6001221)

Biological Activity

Physicochemical Properties

References

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