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Chemical Structure : VU6001221
Catalog No.: PC-62786Not For Human Use, Lab Use Only.
VU6001221 is a potent choline transporter (CHT) inhibitor with IC50 of 270 nM.
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VU6001221 is a potent choline transporter (CHT) inhibitor with IC50 of 270 nM.
VU6001221 shows comparable potency for choline uptake inhibition as ML352, yet improved PK and CNS penetration.
VU6001221 elicits a dose-responsive increase in NOR, raises the possibility of agonism of synaptic α7 nicotinic ACh receptors by elevated extracellular choline.
| M.Wt | 391.89 | |
| Formula | C20H26ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bertron JL, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-40.
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