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SB1301

Chemical Structure : SB1301

CAS No.: 2024548-03-4

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SB1301 (SB 1301, LIN28-Let-7 inhibitor)

Catalog No.: PC-62859Not For Human Use, Lab Use Only.

SB1301 (LIN28-Let-7 inhibitor) is a small-molecule inhibitor disrupting the protein-RNA interaction of LIN28 and Let-7 with FRET IC50 of 4 uM.

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5 mg $228 In stock
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25 mg $558 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB1301 (LIN28-Let-7 inhibitor) is a small-molecule inhibitor disrupting the protein-RNA interaction of LIN28 and Let-7 with FRET IC50 of 4 uM.
SB1301 (LIN28-Let-7 inhibitor) enhances the production of let-7 miRNAs in Lin28-expressing cancer cells and reduces the level of let-7 target oncogene products.

Physicochemical Properties

M.Wt 583.601
Formula C31H29N5O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(7-(4-((benzyloxy)carbonyl)piperazin-1-yl)-4,4-dimethyl-8-nitrochromeno[4,3-c]pyrazol-1(4H)-yl)benzoic acid

References

1. Lim D, et al. J. Am. Chem. Soc., 2016, 138 (41), pp 13630–13638

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