| Cat. No. |
Product Name |
Information |
| PC-61554 |
ML154
NPSR antagonist
|
ML154 (NCGC00185684) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor, GPR154) antagonist with IC50 of 22.1 nM and 36.5 nM in Ca2+ assay and cAMP assay, respectively. |
| PC-61519 |
NPD926
ROS inducer
|
NPD926 is a small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion. |
| PC-61485 |
VJ115
ENOX1 inhibitor
|
VJ115 (VJ-115) is a small molecule inhibitor of NADH oxidase ENOX1 with IC50 of 10 uM, increases intracellular NADH in endothelial cells and inhibits endothelial cell tubule formation. |
| PC-61473 |
BI 1467335
VAP-1 inhibitor
|
BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM. |
| PC-61472 |
PXS-4681A
VAP-1 inhibitor
|
PXS-4681A is a potent, selective, and irreversible inhibitor of semicarbazide-sensitive amine oxidase (SSAO, VAP-1) with Ki of 37 nM, IC50 of <10 nM. |
| PC-61463 |
VPC-18005
ERG antagonist
|
VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM). |
| PC-61429 |
Lucerastat
GCS inhibitor
|
Lucerastat (NB-DGJ, ACT-434964) is a galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM). |
| PC-61428 |
Ibiglustat
Glucosylceramide synthase inhibitor
|
Ibiglustat (Venglustat, Genz-682452) is an orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access. |
| PC-61427 |
EXEL-0346
Glucosylceramide synthase inhibitor
|
EXEL-0346 (EXEL0346) is a novel potent, orally active Glucosylceramide synthase (GCS) inhibitor with IC50 of 2 nM. |
| PC-61426 |
CCG-203586
Glucosylceramide synthase inhibitor
|
CCG-203586 is a potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM. |
| PC-61425 |
PDMP hydrochloride
Glucosylceramide synthase inhibitor
|
PDMP hydrochloride is a ceramide analog that inhibits glucosylceramide synthase (GCS), reduces the synthesis of sphingosine and its derivatives, increases cellular ceramide, and induces cell cycle arrest. |
| PC-61424 |
Fumonisin B1
Ceramide synthase inhibitor
|
Fumonisin B1 is a mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS). |
