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FEN1-IN-1

Chemical Structure : FEN1-IN-1

CAS No.: 824983-91-7

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FEN1-IN-1

Catalog No.: PC-62300Not For Human Use, Lab Use Only.

FEN1-IN-1 is a potent, selective Flap Endonuclease-1 (FEN1) inhibitor with IC50 of 11 nM.

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10 mg $118 In stock
25 mg $188 In stock
50 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FEN1-IN-1 is a potent, selective Flap Endonuclease-1 (FEN1) inhibitor with IC50 of 11 nM.
FEN1-IN-1 dispalys 1,000-fold specificity over a related endonuclease, xeroderma pigmentosum G (XPG).
FEN1-IN-1 significantly potentiates the action of methyl methanesulfonate (MMS) and temozolamide in a bladder cancer cell line.

Physicochemical Properties

M.Wt 332.33
Formula C15H12N2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

References

1. Exell JC, et al. Nat Chem Biol. 2016 Oct;12(10):815-21.

2. Tumey LN, et al. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81.

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