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Isomigrastatin

Chemical Structure : Isomigrastatin

CAS No.: 415952-70-4

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Isomigrastatin (iso-Migrastatin)

Catalog No.: PC-62237Not For Human Use, Lab Use Only.

Isomigrastatin (iso-Migrastatin) is an analogue of migrastatin that shows potent antiproliferative effect on tumor cell lines and selectively inhibits translation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Isomigrastatin (iso-Migrastatin) is an analogue of migrastatin that shows potent antiproliferative effect on tumor cell lines and selectively inhibits translation.
    Isomigrastatin inhibits the migration of human metastatic breast cancer cells, prostate cancer cells, and colon cancer cells but not normal mammary-gland epithelial cells, fibroblasts, and leukocytes.

    Physicochemical Properties

    M.Wt 489.609
    Formula C27H39NO7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[(E,5S)-7-[(2R,3S,4S,5S,6E,10E)-4-hydroxy-5-methoxy-3-methyl-12-oxo-1-oxacyclododeca-6,10-dien-2-yl]-5-methyl-4-oxooct-6-enyl]piperidine-2,6-dione

    References

    1. Schneider-Poetsch T, et al. Nat Chem Biol. 2010 Mar;6(3):209-217.

    2. Shan D, et al. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3772-6.

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