| Cat. No. |
Product Name |
Information |
| PC-22048 |
SCD-19
MIF inhibitor
|
SCD-19 is a small molecule migration inhibitory factor (MIF) inhibitor, blocks the induction of pro-inflammatory M1-like phenotype in BMDMs. |
| PC-22011 |
ZZW-115 hydrochloride
NUPR1 inhibitor
|
ZZW-115 (ZZW115) hydrochloride is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation. |
| PC-21989 |
BRD1732
|
BRD1732 is an ubiquitinated bifunctional small molecule that could be directly ubiquitinated in cells, resulting in dramatic accumulation of inactive ubiquitin monomers and polyubiquitin chains causing broad inhibition of the ubiquitin-proteasome system. |
| PC-21959 |
Tunicamycin
N-glycosylation inhibitor, TarO inhibitor
|
Tunicamycin is a homologous nucleoside antibiotic and GlcNAc phosphotransferase (GPT) inhibitor, inhibits N-glycosylation and induces ER-stress, inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity. |
| PC-21894 |
IDE397
MAT2A inhibitor
|
IDE397 (GSK4362676, GSK-676, IDE397) is a potent, selective small molecule methionine adenosyltransferase 2a (MAT2A) inhibitor, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts. |
| PC-21876 |
MIF agonist MIF20
MIF agonist
|
MIF agonist MIF20 is an allosteric small molecule agonist of macrophage migration inhibitory factor (MIF), binds to MIF and increases its affinity for the cognate MIF receptor CD74, increasing the strength of downstream signal transduction. |
| PC-21871 |
FEN1-IN-4
FEN1 inhibitor
|
FEN1-IN-4 is a specific, competitive inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM, binds to atalytic metals and blocks DNA unpairing. |
| PC-21825 |
EC5026
sEH inhibitor
|
EC5026 (BPN-19186) is a potent, selective orally active soluble epoxide hydrolase (sEH) inhibitor with IC50 of 0.04 nM, shows potential for the treatment of neuropathic pain. |
| PC-21824 |
AR9281
sEH inhibitor
|
AR9281 (AR-9281, APAU) is a potent, selective and orally active soluble epoxide hydrolase (sEH) inhibitor with IC50 of 8 nM and 3 nM for human and mouse sEH enzyme, respectively. |
| PC-21809 |
Tpm1.8/9-1
Tpm1.8/9 inhibitor
|
Tpm1.8/9-1 (CID 6494468) is a specific small molecule inhibitor of Tpm1.8/9, antagonizes Tpm1.8/9's effects on EMT, Wnt signaling, and resistance to chemotherapy. |
| PC-21800 |
LY3509754
IL-17A inhibitor
|
LY3509754 is a potent, selective and oral small molecule inhibitor of IL-17A with high binding potency(KD=2.14 nM), dose-dependently prevents human IL-17A and IL-17AF from binding human IL-17RA. |
| PC-21786 |
UT-59
Scap inhibitor
|
UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis. |
