| Cat. No. |
Product Name |
Information |
| PC-27766 |
PI5P4Kγ inhibitor n40
PI5P4Kγ inhibitor
|
PI5P4Kγ inhibitor n40 is a potent, selective orthosteric-allosteric dual inhibitor of PI5P4Kγ with Kd of 6.55 nM, has >1000-fold selectivity over PI5P4Kα and PI5P4Kβ. |
| PC-27764 |
IMYX-3
RAB27A inhibitor
|
IMYX-3 is a first-in-class small molecule oral inhibitor of RAB27A, inhibits PMA-activated human neutrophil ROS with IC50 of 0.36 uM in human neutrophils, reduces neutrophil-mediated damage by decreasing ROS, degranulation, and NET formation. |
| PC-27757 |
SLK/STK10-IN-1
SLK/STK10 inhibitor
|
SLK/STK10-IN-1 is a potent, selective dual inhibitor of SLK (STE20-like kinase) and STK10 (serine/threonine kinase 10) with IC50 of 1 uM for both in NanoBRET assays in HEK293 cells, shows good kinome-wide selectivity. |
| PC-27755 |
Saikosaponin D
CAS 20874-52-6
|
Saikosaponin D is an active component isolated from Bupleurum falcatum, inhibits activated T lymphocyte proliferation by downregulating the NF-κB, NF-AT, and AP-1 signaling pathways, suppresses enterovirus A71 infection (EV-A71) by inhibiting autophagy, also potently inhibits the proliferation and invasion of cancer cells, induces the apoptosis of cancer cells, and suppresses angiogenesis. |
| PC-27734 |
YS-01
Pendrin inhibitor
|
YS-01 is a potent, specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), potently inhibits pendrin-mediated Cl-/SCN-, Cl-/I-, Cl-/HCO3-, and Cl-/OH- exchange activity in a dose-dependent manner. |
| PC-27733 |
PDSinh-A01
Pendrin inhibitor
|
PDSinh-A01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4) with IC50 of 6.6 uM. |
| PC-27732 |
PDSinh-C01
Pendrin inhibitor
|
PDSinh-C01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), inhibits Cl−/anion exchange mediated by mouse pendrin with IC50 of 1-3 uM, without affecting other major kidney tubule transporters. |
| PC-27728 |
UCB-J
SV2A modulator
|
UCB-J is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A) with pIC50 of 8.15 and 7.6 human and rat SV2A respectively. |
| PC-27727 |
ABBV-552
SV2A modulator
|
ABBV-552 (SDI-118) is a high-affinity, orally available positive synaptic vesicle glycoprotein 2 A (SV2A) modulator with IC50 of 13 nM in in vitro radioligand binding study using human recombinant SV2A (hSV2A). |
| PC-27712 |
XJ-4-85
PFKL activator
|
XJ-4-85 is a highly selective, covalent, allosteric phosphofructokinase-1 liver type (PFKL) activator with EC50 of 342.3 nM in substrate assays (4h), releases carnitine palmitoyltransferase 2 (CPT2) inhibitor destabilize cancer cell metabolism. |
| PC-27709 |
STK947495
NPM1 oligomerization inhibitor
|
STK947495 is a small-molecule modulator of Nucleophosmin 1 (NPM1) oligomerization, promotes dissociation of NPM1 oligomers, reduces NPM1 oligomerization in both lysate-based split luciferase and biochemical assays. |
| PC-27674 |
TS-002266
TUT4/7 inhibitor
|
TS-002266 is a potent and selective RNA terminal uridylyl transferase enzymes 4 and 7 (TUT4/7) inhibitor, blocks miRNA uridylation in vitro with biochemical IC50 of 69 and 16 nM for TUT4 and TUT7, respectively. |
