| Cat. No. |
Product Name |
Information |
| PC-49289 |
AZD4831
Myeloperoxidase inhibitor
|
AZD4831 (Mitiperstat, AZD-4831) is a potent, selective and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 1.5 nM, >450-fold vs thyroid peroxidase in vitro. |
| PC-49267 |
MLL1 CXXC inhibitor 1
MLL1 CXXC inhibitor
|
MLL1 CXXC inhibitor 1 is a small-molecule inhibitor of the MLL1 CXXC domain with IC50 of 7.1 uM, inhibits MLL CXXC domain-DNA binding activity. |
| PC-49246 |
DDX3X helicase 79
DDX3X inhibitor
|
DDX3X helicase 79 is a potent, selective inhibitor of DDX3X helicase activity with IC50 of 5 nM, shows antiviral activity against DENV-2 and WNV with EC50 of 1.6 and 2.3 uM, respectively. |
| PC-49243 |
FHP01
DDX3X inhibitor
|
FHP01 (BA103) is a potent, small molecule inhibitor of DDX3X helicase activity with IC50 of 0.3 uM in in vitro enzyme assays, exhibits very effective antiproliferative and killing activity against different breast cancer cell types (IC50=3.058 and 3.21 μM in MDA MB 468 and MDA MB 231, respectively). |
| PC-49240 |
ICMT inhibitor C75
|
ICMT inhibitor C75 is a potent, specific and cell-permeable inhibitor of the isoprenylcysteine carboxylmethyltransferase (ICMT) with IC50 of 0.5 uM. |
| PC-49232 |
JNJ-1289
Spermine oxidase inhibitor
|
JNJ-1289 (JNJ1289) is a potent, highly selective allosteric inhibitor of human spermine oxidase (hSMOX) with IC50 of 50 nM, inactive against hPAOX and LSD1 (IC50>2,000 nM). |
| PC-49225 |
FOXM1 inhibitor NB-73
FOXM1 inhibitor
|
FOXM1 inhibitor NB-73 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 14 nM and IC50 of 73 nM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein. |
| PC-49219 |
Kakeimide
GH3 inhibitor
|
Kakeimide is a potent GH3 inhibitor that selectively targets IAA-conjugating GH3 proteins at subnanomolar concentrations in vitro, shows auxin-like activity by inhibiting endogenous IAA catabolism. |
| PC-49211 |
TR-107
ClpP activator
|
TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement. |
| PC-49203 |
IMP2 inhibitor 4
IMP2 inhibitor
|
IMP2 inhibitor 4 is a small molecule inhibitor of insulin-like growth factor 2 (IGF2) mRNA binding protein IMP2 (IGF2BP2), inhibits IMP2/RNA interaction. |
| PC-49199 |
BTB09089
TDAG8/GPR65 agonist
|
BTB09089 (BTB 09089) is a specific small molecule agonist of T cell death-associated gene 8 (TDAG8, GPR65). |
| PC-49190 |
IGF2BP2 inhibitor JX5
IGF2BP2 inhibitor
|
IGF2BP2 inhibitor JX5 is a specific small-molecule inhibitor of N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) with Kd of 93.2 uM in internal fluorescence quenching measurement assays, suppresses T-ALL cells proliferation via downregulation of NOTCH1 expression. |
