| Cat. No. |
Product Name |
Information |
| PC-23808 |
ARC39
Acid sphingomyelinase inhibior
|
ARC39 is a direct, selective acid sphingomyelinase (ASM) inhibitor with IC50 of 20 nM, inhibits both lysosomal and secretory ASM in vitro. |
| PC-23783 |
BL001
LRH-1 agonist
|
BL001 is a specific small molecule agonist of liver receptor homologue-1 (LRH-1) with EC50 of 0.1 uM, specifically binds to and activates LRH-1. |
| PC-23762 |
SH514
IRF4 inhibitor
|
SH514 is a specific small molecule inhibitor of interferon regulatory factor 4 (IRF4) with IC50 of 2.63 uM, inhibits proliferation of IRF4-high-expressing NCI-H929 and MM.1R MM cells with IC50 of 0.08 uM and 0.11 uM, respectively. |
| PC-23738 |
MTB-9655
ACSS2 inhibitor
|
MTB-9655 is a potent, selective and orally bioavailable Acetyl-Coenzyme A Synthetase 2 (ACSS2) inhibitor with biochemical IC50 of 0.15 nM and EC50 of 3 nM in cellular assays. |
| PC-23716 |
G3BP1 inhibitor 129
G3BP1/2 inhibitor
|
G3BP1 inhibitor #129 is a small molecule ligand of G3BP1/2 (Ras-GTPase-activating protein SH3 domain-binding protein 1/2), binds with G3BP1 NTF2L domain with SPR KD of 3.7 uM, prevents stress granules (SGs) formation by disrupting G3BP1/caprin1 interaction. |
| PC-23673 |
TD-198946
Runx1 modulator
|
TD-198946 is a small molecule disease-modifying osteoarthritis compound, effectively repairs cartilage by promoting chondrogenic differentiation and halt osteoarthritis (OA) progression, exerts its effect through the regulation of Runx1 expression. |
| PC-23586 |
NB-598
Squalene epoxidase inhibitor
|
NB-598 (NB598) is a potent competitive inhibitor of squalene epoxidase (SQLE, SE, squalene monooxygenase) with IC50 of 4.4 nM (rat SE), inhibits microsomal squalene epoxidase from dog liver and Hep G2 cells with IC50 of 2.0 and 0.75 nM, respectively. |
| PC-23558 |
LZX-2-73
NUPR1 inhibitor
|
LZX-2-73 is a specific and effective NUPR1 inhibitor with Kd of 2.7 uM, inhibits MIA PaCa-2 cell proliferation with IC50 of 10.9 uM. |
| PC-23557 |
AJO14
NUPR1 inhibitor
|
AJO14 is a specific and effective NUPR1 inhibitor with Kd of 4.9 uM. |
| PC-23555 |
R162
GLUD1 inhibitor
|
R162 is a potent, specific inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) with Ki of 28.6 uM, inhibits cancer cell proliferation and tumor growth. |
| PC-23530 |
LDR102
ROR1 inhibitor
|
LDR102 (ROR1 inhibitor 19h) is a potent, specfic inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with SPR KD of 100 nM, binds the intracellular kinase domain and inhibits ROR1 kinase activity. |
| PC-23529 |
ARI-1
ROR1 inhibitor
|
ARI-1 is a specific inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1), directly targets the frizzled domain with high binding affinity, inhibits EGFR-TKIs-resisted NSCLC with high ROR1 expression. |
