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Cat. No. Product Name Information
PC-20505

MEISi-2

MEIS1 inhibitor

MEISi-2 (MEIS inhibitor 2) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity.
PC-20504

MEISi-1

MEIS1 inhibitor

MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity.
PC-20490

R805

gp130 modulator

R805 is a small molecule modulator of gp130 receptor pro-inflammatory signaling, targets a signaling tyrosine 814 (Y814) within gp130, modulates gp130 Y814 upstream of the SRC and MAPK circuit, elicits a protective effect on tissues after injury.
PC-20489

OSM-SMI-10B

Oncostatin M inhibitor

OSM-SMI-10B (SMI-10B) is a first-in-class small molecule inhibitor binds to oncostatin M (OSM) with Kd of 13.6 uM, significantly reduces OSM-induced STAT3 phosphorylation in cancer cells.
PC-20459

Betulin

SREBP inhibitor

Betulin (NSC 4644) is a specific small molecule inhibitor of SREBP (Sterol regulatory element-binding protein), specifically inhibits the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig.
PC-20457

APC655

ATF6 activator

APC655 is a potent activator of protein folding and unfolded protein response (UPR) modulator, APC655 activates ATF6 pathway and chaperone expression.
PC-20454

Caf1 inhibitor 8j

Caf1 inhibitor

Caf1 inhibitor 8j is a potent, selective inhibitor of human poly(A)-selective ribonuclease Caf1 with IC50 of 0.59 uM, 40-fold selectivity over the related deadenylase PARN.
PC-20420

SC144

gp130 inhibitor

SC144 (SC-144) is the first-in-class orally active small-molecule gp130 inhibitor with a broad-spectrum anticancer activity.
PC-20404

ASP7967

RNA aptamer AC17-4 ligand

ASP7967 (ASP-7967) is a cell-permeable and low-toxic compound of RNA aptamer AC17-4 with SPR binding Kd of 12 nM, activates gene expression (>10-fold) in aptazyme-based riboswitches with EC50 of 2.3 uM.
PC-20400

DHAB

ADPR-cyclase inhibitor

DHAB is a potent, specific small molecule inhibitor of kidney ADPR-cyclase with IC50 of 2.5 nM, does not inhibit CD38, spleen, heart or brain ADPR-cyclase activity in vitro.
PC-20399

SAN4825

ADPR-cyclase inhibitor

SAN4825 is a selective small-molecule inhibitor of cardiac ADP-ribosyl cyclase (ADPR cyclase) with IC50 of 0.13 uM.
PC-20389

Dantrolene

Glutathione reductase inhibitor, RyR antagonist

Dantrolene (F368) is a muscle relaxant, non-competitively inhibitor of human erythrocyte glutathione reductase with Ki and IC50 values are 111.6 μM and 52.3 μM, respectively.

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