Chemical Structure : BK697
CAS No.:
1839048-73-5
BK697
(BK 697)
Catalog No.: PC-21625Not For Human Use, Lab Use Only.
BK697 is a small molecule targeting FIRΔexon2, potentially interacts with FIRΔexon2, significantly suppresses the FIRΔexon2 expression and inhibits tumor cell growth and several rRNA expressions.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BK697 is a small molecule targeting FIRΔexon2, potentially interacts with FIRΔexon2, significantly suppresses the FIRΔexon2 expression and inhibits tumor cell growth and several rRNA expressions.
BK697 effectively suppressed HepG2 cell growth with an IC50 of 17.8 µM.
BK697 suppresses the expressions of FIR and FIRΔexon2 mRNA levels in HepG2 cells, reduces the expressions of RPS6, RPS10, RPS15A, RPL30, and RPL23A.
BK697 could salvage FIR homodimerization and was used as a potential therapeutic agent.
BK697 affected FIR family, E-cadherin, Snai1, and BRG1 expression.
FIRΔexon2, a dominant negative splicing form of FIR, is scarcely expressed in normal cells but expressed in cancer with c-myc activation.
Physicochemical Properties
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M.Wt
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440.57
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Formula
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C24H24O4S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-3,3'-(5-(4-(tert-butyl)styryl)-1,3-phenylene)bis(2-thioxopropanoic acid)
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References
1. Kouichi Kitamura, et al. Int J Mol Sci. 2023 Dec 11;24(24):17341.
2. Guzhanuer Ailiken, et al. Oncogenesis. 2020 Feb 18;9(2):26.
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