Catalog No.: PC-21523Not For Human Use, Lab Use Only.
DS68591889 (PTDSS1i) is a potent, selective phosphatidylserine synthase 1 (PTDSS1) inhibitor, highly sellective over PTDSS2, induces phospholipid imbalance in a wide range of cancer cells.
DS68591889 (PTDSS1i) is a potent, selective phosphatidylserine synthase 1 (PTDSS1) inhibitor, highly sellective over PTDSS2, induces phospholipid imbalance in a wide range of cancer cells.
DS68591889 (PTDSS1i) (1 uM) caused a substantial loss of PS and phosphatidylethanolamine, along with a slight decrease in phosphatidylglycerol (PG) and sphingomyelin (SM) and an increase in phosphatidic acid (PA) in Hela cells.
DS68591889 (PTDSS1i) (10, 30, or 100 mg/kg, oral) suppressed Jeko-1 cell engraftment in the bone marrow in B cell lymphoma in vivo.
DS68591889 (PTDSS1i) negatively regulates BCR-induced Ca2+ signaling and cell death, does not overtly affect the morphology of organelles, cell surface expression of BCR signaling components, or BCR-induced phosphorylation of downstream molecules.
DS68591889 (PTDSS1i) efficiently suppressed tumor growth and prolonged survival in mouse xenograft model.
