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Chemical Structure : PQ912
Catalog No.: PC-21626Not For Human Use, Lab Use Only.
Varoglutamstat (PQ912) is a potent glutaminyl cyclase (QC) inhibitor with Ki values of 20-65 nM for human, rat, and mouse QC activity.
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Varoglutamstat (PQ912) is a potent glutaminyl cyclase (QC) inhibitor with Ki values of 20-65 nM for human, rat, and mouse QC activity.
Varoglutamstat (PQ912) shows fast association and dissociation kinetics with a KD value of 17 nM in SPR assays.
Varoglutamstat (PQ912) potently inhibits N3pE-Aβ40/42 formation in the APP-NLE/hQC model with EC50 of 0.14-0.25 uM.
Chronic oral treatment of hAPPSLxhQC double-transgenic mice with Varoglutamstat (PQ912) 200 mg/kg/day via chow shows a significant reduction of pE-Aβ levels and concomitant improvement of spatial learning in a Morris water maze test paradigm.
| M.Wt | 336.40 | |
| Formula | C19H20N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang Y, et al. Eur J Pharmacol. 2022 Sep 15;931:175178.
2. Hoffmann T, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):119-130.
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