Cat. No. |
Product Name |
Information |
PC-72498 |
Macrocyclic peptide D4-2
CD47-SIRPα inhibitor
|
Macrocyclic peptide D4-2 is a macrocyclic peptide consisting of 15 amino acids that binds to the ectodomain of mouse SIRPα (Kd=10 nM, IgV-B6 SIRPα) and efficiently blocks CD47-SIRPα interaction in an allosteric manner (IC50=0.18 uM). |
PC-72496 |
TH8321
NUDT15 inhibitor
|
TH8321 (TH-8321) is a potent, selective NUDT15 inhibitor with IC50 of 35 nM. |
PC-72492 |
SU056
YBX1 inhibitor
|
SU056 (SU-056) is a specific small molecule that potently inhibits tumor growth and progression via Y box binding protein 1 (YBX1, YB1) inhibition. |
PC-72476 |
JTE-607
CPSF3 inhibitor
|
JTE-607 (JTE607) is a multiple cytokine inhibitor that potently suppresses production of proinflammatory cytokines, targets pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3). |
PC-72464 |
PIP4K-IN-a131
PIP4K inhibitor
|
PIP4K-IN-a131 (PIP4K inhibitor a131) is a PIP4K lipid kinase inhibitor with IC50 of 1.9 uM (PI5P4Kα), selectively kills cancer cells, while protecting normal cells. |
PC-72463 |
BAY-091
PIP4K2A inhibitor
|
BAY-091 (BAY091) is a potent and highly selective inhibitor of PIP4K2A with IC50 of 16 nM in the high ATP (2 mM) HTRF assay. |
PC-72461 |
MLS000544460
EYA2 inhibitor
|
MLS000544460 (EYA2i) is a specific, allosteric inhibitor of Eya2 phosphatase with IC50 of 4.1 uM, KD of 2.0 uM, does not bind Eya3 ED, Eya1 and Eya4 ED. |
PC-72452 |
NCGC00249987
EYA2 inhibitor
|
NCGC00249987 (Compound 9987) is a small-molecule allosteric inhibitor that specifically inhibits the Tyr phosphatase activity of EYA2 with IC50 of 3.1 uM (Eya2 ED), but not other Eya family members. |
PC-72451 |
NCGC00378430
SIX1-EYA2 inhibitor
|
NCGC00378430 (Compound 8430) is a novel small molecule compound that reduces the SIX1/EYA2 interaction in vitro with IC50 of 52 uM in the Alphascreen assay. |
PC-72445 |
VLX600
Iron chelator
|
VLX600 (VLX-600) is a small molecule iron chelator and mitochondrial oxidative phosphorylation inhibitor, targets quiescent tumor cells and to inhibit mitochondrial respiration. |
PC-72443 |
ONC212
GPR132 activator
|
ONC212 (ONC-212) is a potent anti-cancer small molecule, activator of an orphan GPCR GPR132 and Gαq signaling. |
PC-72383 |
SRI-37330
TXNIP inhibitor
|
SRI-37330 (SRI 37330) is an orally available small molecule that regulates TXNIP expression, inhibits endogenous TXNIP mRNA expression (IC50=0.64 uM, INS-1 cells qRT-PCR assays). |