| Cat. No. |
Product Name |
Information |
| PC-47074 |
RPI-194
Troponin activator
|
RPI-194 is a novel troponin activator that binds to cardiac/slow skeletal muscle troponin, binds to cardiac troponin with KD of 24 uM, stabilizing the activated complex between troponin C and the switch region of troponin I. |
| PC-47073 |
cjoc42
Gankyrin inhibitor
|
cjoc42 is a specific small molecule that is capable of binding to gankyrin (ITC Kd=580 nM), inhibit gankyrin activity in a dose-dependent manner. |
| PC-47071 |
Carmofur
ASAH1 inhibitor
|
Carmofur (HCFU) is a pyrimidine analogue with antineoplastic activity, Carmofur is a highly potent acid ceramidase (ASAH1) inhibitor with IC50 of 29 nM (rat recombinant ASAH1). |
| PC-47066 |
UNC7938
Endosomolytic compound
|
UNC7938 (UNC10217938 ) is a small molecule that enhance the escape of oligonucleotides from intracellular membrane compartments, enhance the delivery of oligonucleotides. |
| PC-47060 |
GNF-9228
β-cell proliferation activator
|
GNF-9228 is a small molecule that stimulates human β-cell proliferation, selectively activates human β-cell relative to α- or δ-cell proliferation. |
| PC-47057 |
MK-0159
CD38 inhibitor
|
MK-0159 is a highly potent, orally bioavailable CD38 enzymatic inhibitor with IC50 of 3 nM (murine CD38) in in vitro assays. |
| PC-47056 |
ZY-444
Pyruvate carboxylase inhibitor
|
ZY-444 is a specific metabolic inhibitor of pyruvate carboxylase, a key anaplerotic enzyme of the tricarboxylic acid cycle (TCA cycle), suppresses breast cancer growth and metastasis through inhibiting the Wnt/β‐catenin/Snail signaling pathway. |
| PC-47049 |
IPHBA
IL-31 inhibitor
|
IPHBA is a small-molecule inhibitor that suppresses EPAS1-driven IL-31 induction, selectively inhibits TCR-mediated IL-31 induction in murine CD4+ T cells with IC50 of 10.6 uM. |
| PC-47047 |
FeTPPS
|
FeTPPS is a ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomerization to produce nitrate both in vitro and in vivo. |
| PC-47039 |
GQ352
Gαq/11 inhibitor
|
GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM. |
| PC-47038 |
SP-8008
SIPA inhibitor
|
SP-8008 (PCA-8008) is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation. |
| PC-38907 |
2-TCPA
CAD inhibitor
|
2-TCPA is a potent, specific inhibitor of carbamoyl-phosphate synthetase, aspartate transcarbamoylase, and dihydroorotase (CAD), suppresses SARS-CoV-2 replication in Caco-2 cells with IC50 of 2.36 uM. |
