Catalog No.: PC-49456Not For Human Use, Lab Use Only.
CRY1 destabilizer M47 is a selective small molecule that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo, binds to the primary pocket in the PHR domain and specifically destabilizes CRY1 by enhancing its ubiquitination.
CRY1 destabilizer M47 is a selective small molecule that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo, binds to the primary pocket in the PHR domain and specifically destabilizes CRY1 by enhancing its ubiquitination.
CRY1 destabilizer M47 lengthens the period of the circadian rhythm at the cellular level.
CRY1 destabilizer M47 enhances apoptosis in a Ras-transformed p53-null mouse skin fibroblast cell line.
CRY1 destabilizer M47 increases degradation of the CRY1 in the nucleus in mice liver.
CRY1 destabilizer M47 50 (mg/kg/day, i.p.) enhances life span in cancer-prone p53−/− mice.
