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Eliglustat

Chemical Structure : Eliglustat

CAS No.: 491833-29-5

Eliglustat (Genz 99067, GENZ-112638)

Catalog No.: PC-49448Not For Human Use, Lab Use Only.

Eliglustat (GENZ 112638) is a ceramide analog and an orally bioavailable inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase) with IC50 of 20 nM in free-cell assays.

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Biological Activity

Eliglustat (Genz99067) is a ceramide analog and an orally bioavailable inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase) with IC50 of 20 nM in free-cell assays.
Eliglustat (Genz99067) decrease the production of glycosphingolipids (GSLs) including glucosylceramide, also known as glucocerebroside.
Eliglustat (Genz99067) decreases the production of glucosylceramide and other GSLs, which have important roles in various diseases and cellular processes, including immune processes and functions.

Physicochemical Properties

M.Wt 404.551
Formula C23H36N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide

References

1. Jianxun Du, et al. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127209.

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