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UNC-CA157

Chemical Structure : UNC-CA157

CAS No.: 2190517-67-8

UNC-CA157

Catalog No.: PC-49413Not For Human Use, Lab Use Only.

UNC-CA157 is a selective small molecule inhibitor of the archetypal UbiB member COQ8A with IC50 of 580 nM, shows clear preference for COQ8A over COQ8B.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UNC-CA157 is a selective small molecule inhibitor of the archetypal UbiB member COQ8A with IC50 of 580 nM, shows clear preference for COQ8A over COQ8B.
    UNC-CA157 (20 uM) decreases de novo CoQ production in COQ8BKO HAP1 cells.

    Physicochemical Properties

    M.Wt 335.363
    Formula C19H17N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-((3,4,5-trimethoxyphenyl)amino)quinoline-7-carbonitrile

    References

    1. Nathan H Murray, et al. Nat Chem Biol. 2022 Oct 27. doi: 10.1038/s41589-022-01168-3.

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