| Cat. No. |
Product Name |
Information |
| PC-22627 |
GGTI-2154
GGTase I inhibitor
|
GGTI-2154 is a potent, selective inhibitor geranylgeranyltransferase I (GGTase I) with IC50 f 21 nM, >250-fold selective over FTase. |
| PC-22615 |
2-BDBPQD
α-glucosidase inhibitor
|
2-BDBPQD is a potent anti-diabetic agent and inhibitor of carbohydrate-degrading enzyme α-glucosidase with IC50 of 63.7 uM, moderately reduces cholesterol and LDL levels, exhibits superior efficacy in reducing glucose levels compared to acarbose. |
| PC-22607 |
Orpinolide
OSBP inhibitor
|
Orpinolide is a synthetic withanolide analog with potent antileukemic properties, directly targets oxysterol-binding protein OSBP, disrupts Golgi homeostasis via a mechanism that requires active phosphatidylinositol 4-phosphate (PtdIns4P, PI4P) signaling at ER-Golgi membrane interface. |
| PC-22606 |
SABRAC
Acid ceramidase inhibitor
|
SABRAC is a highly potent, irreversible inhibitor of acid ceramidase with Ki of 29.7 nM, induces apoptosis and provides a benefit in mice survival in IDH1 mut oligodendroglioma. |
| PC-22604 |
Oxybipin-2
OSBP inhibitor
|
Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking. |
| PC-22593 |
UNC10245380
CIB1 inhibitor
|
UNC10245380 (UNC5380) is a small molecule ligand/inhibitor of Calcium and Integrin Binding protein 1 (CIB1) with IC50 of 8.0 uM in TR-FRET displacement assay, selectively kills CIB1 depletion-sensitive TNBC cells. |
| PC-22571 |
TMLB-C16
B3GAT3 inhibitor
|
TMLB-C16 is a potent beta-1,3-glucuronosyltransferase (B3GAT3) inhibitor with KD of 3.96 uM, suppresses proliferation and migration in HCC cells. |
| PC-22564 |
T-10418
GPR132 agonist
|
T-10418 is a potent, selective agonist of G protein-coupled receptor G2A (GPR132) with EC50 of 0.82 uM. |
| PC-22541 |
PSB-KK1445
GPR18 agonist
|
PSB-KK1445 is a potent and selective GPR18 agonist with EC50 of 45.4 nM and 124 nM for human and mouse GPR18, respectively, shows high selectivity versus related GPCRs CB1 and CB2, cannabinoid-like receptor, GPR55. |
| PC-22540 |
YK-4-279
EWS-FLI1 inhibitor
|
YK-4-279 is a specific small molecule inhibitor of EWS-FLI1 interaction with RNA helicase A with SPR KD of 9.48 uM for EWS-FLI1, reduces EWS-FLI1 functional activity, also reduces EWS-FLI1 modulated transcription. |
| PC-22534 |
TSLP inhibitor BP79
TSLP inhibitor
|
TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations. |
| PC-22494 |
CCG-1423
Rho/SRF inhibitor
|
CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer. |
