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Chemical Structure : InhiTinib
Catalog No.: PC-38144Not For Human Use, Lab Use Only.
InhiTinib is a small molecule that inhibit interferon (IFN)-gamma production (IC50=52.44 nM) and proliferation of primary CD3+ T cells without inducing cell death.
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InhiTinib is a small molecule that inhibit interferon (IFN)-gamma production (IC50=52.44 nM) and proliferation of primary CD3+ T cells without inducing cell death。
InhiTinib blocks IFN-gamma production from T cells co-cultured with allogeneic BMDCs in a one-way mixed lymphocyte reaction (MLR) and inhibits T-cell proliferation in a CellTrace dilution assay without inducing apoptosis.
InhiTinib decreases IFN-gamma production from activated CB-derived human CD3+ T cells (IC50=1.5 uM).
InhiTinib triggered apoptosis in several murine and human cancer cell lines.
InhiTinib was well tolerated by immunocompetent mice, triggered tumor regression in animals with pre-established EL4 T-cell lymphomas, and prolonged the overall survival of mice harboring advanced tumors.
| M.Wt | 369.82 | |
| Formula | C15H16ClN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Abed El-Hakim El-Kadiry, et al. Front Pharmacol. 2020 Mar 12;11:237.
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