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Chemical Structure : CADD522
CAS No.: 199735-88-1
Catalog No.: PC-38159Not For Human Use, Lab Use Only.
CADD522 (CADD-522) is a small molecule that inhibits RUNX2-DNA binding (IC50=10 nM) and decreases RUNX2 transcriptional activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 200 mg | $548 | In stock | |
| 1 g | Get quote |
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CADD522 (CADD-522) is a small molecule that inhibits RUNX2-DNA binding (IC50=10 nM) and decreases RUNX2 transcriptional activity.
CADD522 had no effect on the RUNX2 occupancy in MCF7-Empty cells, CADD522 significantly inhibited RUNX2 enrichment in the MCF7-RUNX2 cells.
CADD522 reduced RUNX2-mediated increases in glucose uptake and decreased the level of CBF-β and RUNX2 phosphorylation at the S451 residue.
The administration of CADD522 into MMTV-PyMT mice resulted in significant delay in tumor incidence and reduction in tumor burden.
| M.Wt | 326.173 | |
| Formula | C15H13Cl2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-((3,4-dichlorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid |
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1. Kim MS, et al. Oncotarget. 2017 Aug 10;8(41):70916-70940.
2. Kim MS, et al. Oncotarget. 2020 Oct 27;11(43):3863-3885.
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