SOX11 inhibitor Compound E (SOX11i) is a small molecule inhibitor of SOX11, binds directly to SOX11-DBD and interfere with DNA binding.
SOX11 inhibitor Compound E (SOX11i) demosntrates SOX11-specific growth inhibition (IC50=12-15 uM) in SOX11-positive MCL cell lines (JeKo-1, Mino and Z-138).
SOX11 inhibitor Compound E (SOX11i) inhibits pBTK levels in all three SOX11+ cell lines (IC50=28-43 uM), no effect on pBTK level in SOX11-negative JVM-2 cells.
SOX11 belongs to the SOXC family of high mobility group (HMG) transcription factors, which consists of SOX4, SOX11, and SOX12.
SOX11 protein is expressed in the majority (78–93%) of MCL patients and is specific for MCL as compared to other types of Non-Hodgkin's Lymphoma (NHL).
