| Cat. No. |
Product Name |
Information |
| PC-35660 |
DKFZ-633
KLK6 inhibitor
|
DKFZ-633 (DKFZ633) is a selective inhibitor of Kallikrein-related peptidase 6 (KLK6) with IC50 of 0.25 uM, demonstrates good selectivity for KLK6 compared to other KLKs. |
| PC-35656 |
BIO922
PICK1 inhibitor
|
BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors. |
| PC-35652 |
FR58P1a
OXPHOS uncoupler
|
FR58P1a is a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism, selectively inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway. |
| PC-35649 |
Harmine
Twist1 inhibitor
|
Harmine (Telepathine, Banisterine, Leucoharmine) is a fluorescent harmala alkaloid occurs in a number of different plants, reversibly inhibits monoamine oxidase A (MAO-A) but not MAO-B, also inhibits multiple Twist1 functions. |
| PC-35648 |
Vamorolone
|
Vamorolone (VBP15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, also reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo. |
| PC-35645 |
iST2-1
ST2 inhibitor
|
iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively. |
| PC-35611 |
ERD03
EXOSC3 inhibitor
|
ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish. |
| PC-35607 |
P053
CerS1 inhibitor
|
P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6. |
| PC-35588 |
CTPI-2
SLC25A1 inhibitor
|
CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo. |
| PC-35586 |
MAI-150
APC-Asef inhibitor
|
MAI-150 is a peptidomimetic inhibitor of APC-Asef interaction, blocks colorectal cancer migration.. |
| PC-35583 |
NP161
Thioredoxin 1 inhibitor
|
NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM. |
| PC-35582 |
MFN2 agonist B-A l
MFN2 agonist
|
MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM. |
