Chemical Structure : Berotralstat
CAS No.:
1809010-50-1
Berotralstat
(BCX7353, BCX-7353)
Catalog No.: PC-36087Not For Human Use, Lab Use Only.
Berotralstat (BCX7353, BCX-7353) is a potent, highly selective, oral plasma kallikrein inhibitor.
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| 2 mg | $228 | In stock | |
| 5 mg | $368 | In stock | |
| 10 mg | $588 | In stock | |
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Berotralstat (BCX7353, BCX-7353) is a potent, highly selective, oral plasma kallikrein inhibitor.
Berotralstat (BCX7353) displays high selectivity over other structurally related serine proteases.
Berotralstat (BCX7353) is the first orally bioavailable prophylactic treatment for hereditary angioedema (HAE) attacks.
Physicochemical Properties
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M.Wt
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562.573
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Formula
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C30H26F4N6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-[3-(aminomethyl)phenyl]-N-(5-{(R)-(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
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References
1, Kotian PL, et al. J Med Chem. 2021 Sep 9;64(17):12453-12468.
2, Aygören-Pürsün E, et al. N Engl J Med. 2018 Jul 26;379(4):352-362.
3, Farkas H, et al. Clin Transl Allergy. 2021 Jun;11(4):e12035.
4, Zuraw B, et al. J Allergy Clin Immunol. 2021 Jul;148(1):164-172.e9.
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