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Chemical Structure : FDI-6
CAS No.: 313380-27-7
Catalog No.: PC-36076Not For Human Use, Lab Use Only.
FDI-6 (FOXM1 inhibitor FDI6, NCGC00099374) is a small molecule inhibitor of FOXM1 with IC50 of 22.5 uM (FOXM1 DNA binding inhibition).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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FDI-6 (FOXM1 inhibitor FDI6, NCGC00099374) is a small molecule inhibitor of FOXM1 with IC50 of 22.5 uM (FOXM1 DNA binding inhibition).
FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional downregulation, inhibits growth of MCF-7 breast cancer cells with GI50 of 18.0 uM.
FDI-6 specifically downregulates FOXM1-activated genes with FOXM1.
FDI-6 also can suppress pancreatic cancer cell proliferation and induces their apoptotic cell death, sensitizes pancreatic cancer cells to Etoposide and Gemcitabine induced apoptosis.
| M.Wt | 437.43 | |
| Formula | C19H11F4N3OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide |
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1. Gormally MV, et al. Nat Commun. 2014 Nov 12;5:5165.
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