| Cat. No. |
Product Name |
Information |
| PC-27617 |
ABT-E79
PGK1 inhibitor
|
ABT-E79 is a highly potent and selective PGK1 inhibitor, significantly inhibits TNBC cell proliferation. |
| PC-27604 |
OMDM-1
Anandamide uptake inhibitor
|
OMDM-1 is a potent, selective inhibitor of anandamide cellular uptake (ACU) with Ki of 2.4 uM, inhibits anandamide transport. |
| PC-27596 |
Isofagomine
Glycosidase inhibitor
|
Isofagomine (Afegostat) is a broad spectrum inhibitor of glycosidases, inhibits beta-glucosidase, glucoamylase, isomaltase, and alpha-glucosidase, specifically and reversibly binds lysosomal hydrolase acid β-glucosidase (GCase) in the ER with high affinity. |
| PC-27579 |
K303MP20
GPRC5B/C inhibitor
|
K303MP20 (MP20) is a small molecule inhibitor of orphan GPCR GPRC5B and GPRC5C dimerization, inhibits GPRC5B/C-mediated modulation of EP2, IP, and AT1 signaling in vitro and in vivo. |
| PC-27512 |
MAT2A inhibitor ZS34
MAT2A inhibitor
|
MAT2A inhibitor ZS34 is a potent, selective, and orally bioavailable MAT2A inhibitor with IC50 of 13.7 nM. |
| PC-27508 |
Tazbentetol
Synaptic regenerative agent
|
Tazbentetol (SPG302) is a pegylated benzothiazole derivative and synaptic regenerative small molecule, targets the cytoskeleton and induces the formation of new glutamatergic synapses. |
| PC-27505 |
JXL069
MPC inhibitor
|
Suvomipic (JXL069) is a potent, small molecule mitochondrial pyruvate carrier (MPC) inhibitor with IC50 of 42.8 nM. |
| PC-27499 |
AKBA
MAT2A inhibitor
|
AKBA is a bioactive boswellic acid found in frankincense and allosteric, specific inhibitor of methionine adenosyltransferase 2A (MAT2A) with MST Kd of 129 nM, shows anti-inflammatory and anti-cancer properties. |
| PC-27497 |
SARM1 inhibitor MY-13B
SARM1 inhibitor
|
SARM1 inhibitor MY-13B is a stereoselective, covalent SARM1 inhibitor, site-specifically engage C311 in SARM1. |
| PC-27492 |
Rexipictor
Polycystin-1 corrector
|
Rexipictor (VX-407) is a first-in-class small molecule Polycystin-1 (Polycystin 1, PC1, PKD1) corrector, corrects inappropriate PC1 folding to abate cystogenesis and eGFR decline, shows potential for treatment of autosomal dominant polycystic kidney disease (ADPKD). |
| PC-27442 |
FSG67
GPAT inhibitor
|
FSG67 is a small molecule mitochondrial glycerol-3-phosphate acyltransferase (mitochondrial GPAT, GPAM) inhibitor with IC50 30.2 μM for total mitochondrial GPAT and 42.1 μM for GPAT1. |
| PC-27273 |
PBITE-1
ERG PNT domain binder
|
PBITE-1 is a small molecule that selectively binds ERG N-terminal Pointed (PNT) domain with Kd of 264 uM in BLI assays, directly engages ERG, selectively inhibits proliferation and invasion, and induces apoptosis in ERG-driven prostate and hematologic malignancies. |
