| Cat. No. |
Product Name |
Information |
| PC-23228 |
AM-001
EPAC1 inhibitor
|
AM-001 is a potent, selective and allosteric inhibitor of exchange proteins directly activated by cAMP 1 (EPAC1), inhibits Sp-8-CPT-induced Epac1 (EC50=47.8 uM) but not Epac2 activity. |
| PC-23227 |
Tirasemtiv
Fast skeletal troponin activator
|
Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis. |
| PC-23069 |
QC-308
Heme oxygenase inhibitor
|
QC-308 is a potent heme oxygenase (HO) inhibitor witn IC50 of 0.27 uM and 0.46 uM for hHO-1 and hHO-2 respectively. |
| PC-22641 |
TAK-448
KISS1R agonist
|
TAK-448 (MVT-602) is a potent and full KISS1R (metastin receptor) agonist and kisspeptin analogue with IC50 of 3 pM in radioimmunoassay. |
| PC-22534 |
TSLP inhibitor BP79
TSLP inhibitor
|
TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations. |
| PC-22494 |
CCG-1423
MKL1 inhibitor
|
CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer. |
| PC-22383 |
CDD-2807
STK33 inhibitor
|
CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect. |
| PC-22367 |
SHP1705
CRY2 activator
|
SHP1705 is a small molecule cryptochrome 2 (CRY2) activator and stabilizer, represses the expression of DBP, CRY1, and PER1, reduces glucose intolerance in obese, insulin-resistant mice. |
| PC-22337 |
STL001
FOXM1 inhibitor
|
STL001 is a small molecule inhibitor of forkhead box protein M1 (FOXM1), suppresses FOXM1 protein levels in a variety of solid tumor-derived cancer cell lines. |
| PC-22262 |
Fatostatin
SREBP inhibitor
|
Fatostatin (125B11) is a small molecule sterol regulatory element binding protein (SREBP) inhibitor, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells. |
| PC-22243 |
FeM-1269
Ion mobilizer
|
FeM-1269 is a small molecule ion mobilizer, minimally aggregates and dose-dependently mobilizes iron across lipid bilayers, increases serum iron, transferrin saturation, hemoglobin and hematocrit in mouse model of anemia of inflammation. |
| PC-22206 |
UNC-CA2-103
TLK2 inhibitor
|
UNC-CA2-103 is a potent, selective tousled like kinase 2 (TLK2) inhibitor with enzyme IC50 of 18 nM, exhibit excellent selectivity over TLK1 (16% inhibition at 0.5 μM). |
