| Cat. No. |
Product Name |
Information |
| PC-22494 |
CCG-1423
MKL1 inhibitor
|
CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer. |
| PC-22383 |
CDD-2807
STK33 inhibitor
|
CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect. |
| PC-22337 |
STL001
FOXM1 inhibitor
|
STL001 is a small molecule inhibitor of forkhead box protein M1 (FOXM1), suppresses FOXM1 protein levels in a variety of solid tumor-derived cancer cell lines. |
| PC-22262 |
Fatostatin
SREBP inhibitor
|
Fatostatin (125B11) is a small molecule sterol regulatory element binding protein (SREBP) inhibitor, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells. |
| PC-22243 |
FeM-1269
Ion mobilizer
|
FeM-1269 is a small molecule ion mobilizer, minimally aggregates and dose-dependently mobilizes iron across lipid bilayers, increases serum iron, transferrin saturation, hemoglobin and hematocrit in mouse model of anemia of inflammation. |
| PC-22206 |
UNC-CA2-103
TLK2 inhibitor
|
UNC-CA2-103 is a potent, selective tousled like kinase 2 (TLK2) inhibitor with enzyme IC50 of 18 nM, exhibit excellent selectivity over TLK1 (16% inhibition at 0.5 μM). |
| PC-22176 |
SMS121
CD36 inhibitor
|
SMS121 (SMS-121) is a drug-like small molecule inhibitor of the very long/long chain fatty acid transporter CD36 (FAT, scavenger receptor class B member 3/SCARB3) with binding Kd of 5.57 uM. |
| PC-22137 |
HYPE inhibitor I2.10
HYPE inhibitor
|
HYPE inhibitor I2.10 is a small molecule HYPE (Huntingtin Yeast Interacting Partner E, FICD) enzyme inhibitor with IC50 of 12.1 uM, inhibits HYPE-mediated AMPylation of BiP in vtro. |
| PC-22049 |
ST80
OTUD4-CD73 inhibitor
|
ST-80 is a specific small molecule inhibitor of interaction between CD73 and OTUD4, specifically disrupts proteolytic interaction between CD73 and OTUD4, leading to reinvigoration of cytotoxic CD8+ T cell activities. |
| PC-22048 |
SCD-19
MIF inhibitor
|
SCD-19 is a small molecule migration inhibitory factor (MIF) inhibitor, blocks the induction of pro-inflammatory M1-like phenotype in BMDMs. |
| PC-22011 |
ZZW-115 hydrochloride
NUPR1 inhibitor
|
ZZW-115 (ZZW115) hydrochloride is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation. |
| PC-21989 |
BRD1732
|
BRD1732 is an ubiquitinated bifunctional small molecule that could be directly ubiquitinated in cells, resulting in dramatic accumulation of inactive ubiquitin monomers and polyubiquitin chains causing broad inhibition of the ubiquitin-proteasome system. |
