| Cat. No. |
Product Name |
Information |
| PC-26717 |
HF-125
TRIB2 inhibitor
|
HF-125 is a potent, selective small molecule inhibitor of Tribbles 2 (TRIB2), directly binds to destabilize and degrade TRIB2 proteins involving proteasomes and is effective both in vitro and in vivo. |
| PC-26684 |
LMT328
Sulfiredoxin inhibitor
|
LMT328 (LMT-328) is a potent inhibitor of sulfiredoxin (Srx) with IC50 of 6.7 uM. |
| PC-26615 |
ERG245
BCAT1 inhibitor
|
ERG245 is a potent, selective BCAT1 inhibitor with IC50 of 0.5 nM for recombinant human BCAT1 (rhBCAT1), >2000-fold selectivity for BCAT1 over BCAT2. |
| PC-26553 |
ZNF281 inhibitor ZIM
ZNF281 inhibitor
|
ZNF281 inhibitor ZIM (ZNF281 Interfering Molecule) is a specific small molecule inhibitor of transcription factor ZNF281, prevents anthracycline-mediated cardiotoxicity (AIC), enhances lung tumor regression, and prevents lung metastasis in a metastatic melanoma model. |
| PC-26506 |
CCF0054500
OR2L13 agonist
|
CCF0054500 is a specific small molecule agonist of orphan GPCR OR2L13, inhibits platelet aggregation in platelet-rich plasma (PRP) with EC50 of 14 uM. |
| PC-26468 |
NCGC00238624
GALK1 inhibitor
|
NCGC00238624 is a highly selective galactokinase (GALK1) inhibitor with IC50 of 7.69 and 13.67 uM against the human and mouse recombinant GALK1, respectively, lowers gal-1P levels in primary fibroblast cells derived from patients with classic galactosemia. |
| PC-26467 |
GALK1-IN-1
GALK1 inhibitor
|
GALK1-IN-1 is an effective ATP-competitive galactokinase 1 (GALK1) inhibitor with IC50 of 1 uM in luminescence GALK-ATP-depletion assay. |
| PC-26416 |
NFYi5
NF-Y inhibitor
|
NFYi5 is a specific small molecule inhibitor of Nuclear Transcription Factor-Y (NF-Y), inhibits NF-Y-dependent transcriptional activity, dose dependently inhibits activity of the NF-Y reporter in both human and rat cardiac fibroblasts with IC50 of 19.95 and 12.73 uM respectively. |
| PC-26386 |
IVMT-Rx-4
MDA-9/Syntenin inhibitor
|
IVMT-Rx-4 is a small molecule inhibitor of MDA-9/Syntenin, specifically interrupt MDA-9/Syntenin signaling, leading to an inhibition in progression of PC cells to bone metastasis. |
| PC-26377 |
NBDHEX
GST inhibitor
|
NBDHEX is a potent glutathione S-transferase (GST) inhibitor, inhibits human glutathione S-transferases GSTA1-1, GSTP1-1 and GSTM2-2 with IC50 of 25 uM, 0.8 uM and <0.01 uM, is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines. |
| PC-26291 |
UNC11676A
MDA5 inhibitor
|
UNC11676A is a specific small molecule inhibitor of RNA helicase MDA5 with IC50 of 6 uM, >18-fold selective inhibition over LGP2 and DDX1. |
| PC-26266 |
CVN14
CD38 inhibitor
|
CVN14 is a potent, selective, uncompetitive and brain-penetrant CD38 inhibitor with IC50 of 19 nM and 2 nM for human and mouse CD38 respectively. |
