| Cat. No. |
Product Name |
Information |
| PC-28453 |
NFAT inhibitor 14
NFAT inhibitor
|
NFAT inhibitor 14 is a small-molecule calcineurin-nuclear factor of activated T cells (NFAT) signaling inhibitor, inhibits the nuclear translocation and transcriptional activity of both NFATc1 and NFATc2, suppresses NFAT-dependent cytokine production, and shows cellular immunosuppressive activities. |
| PC-28436 |
A10P3C
EGLN2 inhibitor
|
A10P3C is a potent, isoform-selective inhibitor of prolyl hydroxylase EGLN2, effectively suppresses breast cancer cell proliferation, migration and invasion, induces G1 cell cycle arrest and cellular senescence through on-target EGLN2 inhibition. |
| PC-26013A |
GPR83 agonist CPD27
GPR83 agonist
|
GPR83 agonist CPD27 is a potent, selective small molecule GPR83 agonist with binding IC50 of 0.1 nM, and EC50 of 0.8 nM for [35S]GTPγS binding to membranes from CHO cells expressing mouse GPR83. |
| PC-28421 |
CMM-98
OGG1 activator
|
CMM-98 is a specific small molecule modulator / activator of DNA glycosylase OGG1 with AC50 of 38 nM and 83 nM on hOGG1 and mOGG1 respectively. |
| PC-28417 |
NGM1
NOS1AP modulator
|
NGM1 is a small molecule NOS1AP modulator of directly binds NOS1AP (CAPON) with SPR KD of 11.9 uM, alters NOS1AP-NOS1 (Nitric oxide synthase, nNOS) proximity, reduces viability in U87 and U251 GBM cells with IC50 values of 12.7 and 17.3 uM, respectively, with no effect on normal human astrocyte viability. |
| PC-28411 |
FOXC1-I4
FOXC1 inhibitor
|
FOXC1-I4 is a small-molecule inhibitor of Forkhead box C1 (FOXC1), binds FOXC1 (SPR KD=2.68 uM) and suppresses FOXC1 transcriptional activity. |
| PC-28384 |
DANA
Neuraminidase inhibitor
|
DANA (Neu5Ac2en, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid) is a potent Neuraminidas isoenyzmes (Sialidases, NEU) inhibitor with IC50 of 49, 43, 7.7, and 8.3 uM for NEU1, NEU2, NEU3, and NEU4, respectively, shows anti-influenza virus activity. |
| PC-28362 |
JP4-039
Antioxidant
|
GS-nitroxide (JP4-039) is a mitochondrion-targeted antioxidant nitroxide and mitochondria-targeted reactive species (ROS) scavenger and electron scavenger. |
| PC-28361 |
Gramicidin S
Antibiotic
|
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity, selectively accumulates within microbial cell membranes. |
| PC-28352 |
DMNB-7d
GPR52 agonist
|
DMNB-7d is a photoactivatable GPR52 agonist, shows markedly reduced basal activity in the dark and underwent photoactivation under 405 nM irradiation in cells. |
| PC-28350 |
AEP inhibitor 11a
AEP inhibitor
|
AEP inhibitor 11a (AEP inhibitor CP#11A) is a potent, selective δ-secretase (Asparagine endopeptidase, AEP, Legumain) inhibitor with IC50 of 10 nM, and binding affinity Kd of 5.5 nM. |
| PC-28333 |
Hopantenate calcium
PANK inhibitor
|
Hopantenate Calcium (HoPan) is a pantothenate analogue hopantenate (HoPan) widely used as a modulator of coenzyme A (CoA) levels, inhibits pantothenate kinase (PanK), the first enzyme of CoA biosynthesis, also inhibits inhibits the next enzyme phosphopantothenoylcysteine synthetase (PPCS) in CoA pathway. |
