Chemical Structure : LIBX-A401
CAS No.:
LIBX-A401
Catalog No.: PC-24108Not For Human Use, Lab Use Only.
LIBX-A401 is a potent, selective inhibitor of Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) with IC50 of 0.38 uM, MST KD of 0.72 uM, with high selectivity over ACSL3 (IC50>50 uM), protects cells from ferroptosis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LIBX-A401 is a potent, selective inhibitor of Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) with IC50 of 0.38 uM, MST KD of 0.72 uM, with high selectivity over ACSL3 (IC50>50 uM), protects cells from ferroptosis.
LIBX-A401 is derived from rosiglitazone but devoid of PPARγ activity
LIBX-A401 stabilizes the ACSL4 C-terminus, and altersthe fatty acid (FA) gate domain.
LIBX-A401 exhibits significant anti-ferroptotic properties in cells.
LIBX-A401 (2.5 µM) significantly prevented RSL3-induced cell death in bothHEK293 and HT-1080 cells.
LIBX-A401 (2.5 µM) effectively inhibited cell death caused by AA+Fe treatment in LUHMES cells.
Physicochemical Properties
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M.Wt
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339.39
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Formula
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C20H21NO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl (E)-3-(4-(2-(N-methylbenzamido)ethoxy)phenyl)acrylate
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References
1. Mazhari Dorooee D, et al. Angew Chem Int Ed Engl. 2025 Feb 28:e202500518.
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