G3BP1 inhibitor 129 | G3BP1/2 inhibitor

Chemical Structure : G3BP1 inhibitor 129

G3BP1 inhibitor 129 (G3BP1 inhibitor #129)

Catalog No.: PC-23716Not For Human Use, Lab Use Only.

G3BP1 inhibitor #129 is a small molecule ligand of G3BP1/2 (Ras-GTPase-activating protein SH3 domain-binding protein 1/2), binds with G3BP1 NTF2L domain with SPR KD of 3.7 uM, prevents stress granules (SGs) formation by disrupting G3BP1/caprin1 interaction.

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Biological Activity

G3BP1 inhibitor #129 is a small molecule ligand of G3BP1/2 (Ras-GTPase-activating protein SH3 domain-binding protein 1/2), binds with G3BP1 NTF2L domain with SPR KD of 3.7 uM, prevents stress granules (SGs) formation by disrupting G3BP1/caprin1 interaction.

Physicochemical Properties

M.Wt	491.56
Formula	C26H25N3O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((2-(1H-indazol-1-yl)-2-oxoethyl)sulfonyl)-2-benzyl-N-(4-methoxyphenyl)propanamide

References

1. Dong T, et al. J Am Chem Soc. 2024 Dec 22.

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G3BP1 inhibitor 129 (G3BP1 inhibitor #129)

Biological Activity

Physicochemical Properties

References

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