Chemical Structure : ALT-007
CAS No.:
2035010-62-7
ALT-007
(ALT007)
Catalog No.: PC-23850Not For Human Use, Lab Use Only.
ALT-007 is a potent, selective and orally bioavailable inhibitor of serine palmitoyltransferase (SPT) with enzyme IC50 of 0.54 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ALT-007 is a potent, selective and orally bioavailable inhibitor of serine palmitoyltransferase (SPT) with enzyme IC50 of 0.54 nM.
ALT-007 potently inhibited both SPT enzyme (IC50 =1.2 nM) and HCC4006 cell growth (IP = 3.9 nM).
ALT-007 displayed potent growth inhibitory activity against both HCC4006 and PL-21 cells on the same level with Myriocin.
ALT-007 is an orally bioavailable SPT inhibitor with in vivo antitumor efficacy, which provides a useful tool for assessing the pharmaceutical potential of SPT inhibitors especially against cancer.
Physicochemical Properties
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M.Wt
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533.51
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Formula
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C25H26F3N5O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-(4-(5,6-dimethoxynicotinoyl)-1-isopropyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl)-2-(trifluoromethoxy)benzamide
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References
1. Poisson J, et al. ACS Pharmacol Transl Sci. 2024 Dec 29;8(1):203-215.
2. Kojima T, et al. Bioorg Med Chem. 2018 May 15;26(9):2452-2465.
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