ALT-007 is a potent, selective and orally bioavailable inhibitor of serine palmitoyltransferase (SPT) with enzyme IC50 of 0.54 nM.
ALT-007 potently inhibited both SPT enzyme (IC50 =1.2 nM) and HCC4006 cell growth (IP = 3.9 nM).
ALT-007 displayed potent growth inhibitory activity against both HCC4006 and PL-21 cells on the same level with Myriocin.
ALT-007 is an orally bioavailable SPT inhibitor with in vivo antitumor efficacy, which provides a useful tool for assessing the pharmaceutical potential of SPT inhibitors especially against cancer.
