| Cat. No. |
Product Name |
Information |
| PC-35697 |
DKFZ-251
KLK6 inhibitor
|
DKFZ-251 (DKFZ251) is a selective inhibitor of Kallikrein-related peptidase 6 (KLK6) with IC50 of 0.13 uM, demonstrates good selectivity for KLK6 compared to other KLKs. |
| PC-35685 |
KAN0438241
PFKFB3 inhibitor
|
KAN0438241 (KAN-0438241) is a potent, selective PFKFB3 inhibitor with IC50 of 0.19 uM, 20-fold selectivity over PFKFB4 and no significant inhibition on PFKFB1 and 2. |
| PC-35684 |
KAN0438757
PFKFB3 inhibitor
|
KAN0438757 (KAN-0438757) is a potent, selective PFKFB3 inhibitor, the ester prodrug of KAN0438241 with enhanced cell permeability. |
| PC-35673 |
WJ460
Myoferlin inhibitor
|
WJ460 (Myoferlin inhibitor WJ460, WJ-460) is a small molecule targeting myoferlin (MYOF), exerts anti-metastatic activity in the nanomolar range in breast cancer cells with IC50 of 43.37 nM in MDA-MB-231 and 36.40 nM in BT549 cells. |
| PC-35671 |
DS42450411
Hepcidin inhibitor
|
DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM. |
| PC-35660 |
DKFZ-633
KLK6 inhibitor
|
DKFZ-633 (DKFZ633) is a selective inhibitor of Kallikrein-related peptidase 6 (KLK6) with IC50 of 0.25 uM, demonstrates good selectivity for KLK6 compared to other KLKs. |
| PC-35656 |
BIO922
PICK1 inhibitor
|
BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors. |
| PC-35652 |
FR58P1a
OXPHOS uncoupler
|
FR58P1a is a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism, selectively inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway. |
| PC-35649 |
Harmine
Twist1 inhibitor
|
Harmine (Telepathine, Banisterine, Leucoharmine) is a fluorescent harmala alkaloid occurs in a number of different plants, reversibly inhibits monoamine oxidase A (MAO-A) but not MAO-B, also inhibits multiple Twist1 functions. |
| PC-35648 |
Vamorolone
|
Vamorolone (VBP15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, also reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo. |
| PC-35645 |
iST2-1
ST2 inhibitor
|
iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively. |
| PC-35611 |
ERD03
EXOSC3 inhibitor
|
ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish. |
