| Cat. No. |
Product Name |
Information |
| PC-22076 |
Sulfopin
Pin1 inhibitor
|
Sulfopin is a potent, selective and covalent inhibitor of Pin1 with Ki of 17 nM in FP assay, targets Pin1's active site Cys113, blocks Myc-driven tumors. |
| PC-22060 |
Ternatin-4
eEF1A inhibitor
|
Ternatin-4 is a small molecule elongation factor-1alpha (eEF1A) inhibitor, triggers the ubiquitination and degradation of eEF1A on stalled ribosomes, targets the complex of eEF1A bound to aminoacyl-tRNAs (aa-tRNA). |
| PC-22011 |
ZZW-115 hydrochloride
NUPR1 inhibitor
|
ZZW-115 (ZZW115) hydrochloride is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation. |
| PC-21999 |
N-chloroacetyltryptamine
AANAT inhibitor
|
N-chloroacetyltryptamine is a potent in vitro and in vivo AANAT acetyltransferase inhibitor with IC50 of 5.2 uM. |
| PC-21998 |
AANAT inhibitor 1
AANAT inhibitor
|
AANAT inhibitor 1 is a highly potent arylalkylamine N-acetyltransferase (AANAT) inhibitor with IC50 of 500 nM, covalently reacts with AANAT product CoASH. |
| PC-21989 |
BRD1732
|
BRD1732 is an ubiquitinated bifunctional small molecule that could be directly ubiquitinated in cells, resulting in dramatic accumulation of inactive ubiquitin monomers and polyubiquitin chains causing broad inhibition of the ubiquitin-proteasome system. |
| PC-21975 |
Canlitinib
|
Canlitinib is a tyrosine kinase inhibitor, extracted from patent WO2018072614 (IV-2). |
| PC-21972 |
Bezisterim
|
Bezisterim (HE3286) is an orally bioavailable synthetic analogue of an active DHEA metabolite, displays both glucose-lowering and cholesterol-lowering effects. |
| PC-21959 |
Tunicamycin
N-glycosylation inhibitor
|
Tunicamycin is a homologous nucleoside antibiotic and GlcNAc phosphotransferase (GPT) inhibitor, inhibits N-glycosylation and induces ER-stress, inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity. |
| PC-21958 |
Thapsigargin
ER stress inducer
|
Thapsigargin is a natural small molecule endoplasmic reticulum (ER) stress inducer and microsomal Ca2+-ATPase inhibitor, also efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication. |
| PC-21945 |
EBP inhibitor 11
EBP inhibitor
|
EBP inhibitor 11 is a potent, selective, brain-penetrant, orally bioavailable inhibitor of emopamil binding protein (EBP) with mGCMS zymo EC50 of 8 nM, and OPC differentiation EC50 of 44 nM. |
| PC-21942 |
PU.1 inhibitor A11
PU.1 inhibitor
|
PU.1 inhibitor A11 is a small molecule inhibitor of transcription factor PU.1 with EC50 of 2.5 nM in reporter assays, moderates the inflammatory response in human iPSC-derived microglia-like cells (iMGLs) by downregulating inflammatory PU.1-target gene expression without affecting hematopoiesis. |
